Iuliano Lorenzo, Fogliato Giovanni, Querques Giuseppe, Bandello Francesco, Codenotti Marco
Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Via Olgettina, 60 - 20132, Milan, Italy.
Graefes Arch Clin Exp Ophthalmol. 2017 Jul;255(7):1325-1332. doi: 10.1007/s00417-017-3643-8. Epub 2017 Mar 23.
To investigate, using the Dynamic Vessel Analyzer (DVA), the retinal vascular changes that may occur after vitrectomy for idiopathic epiretinal membrane (ERM).
Twenty-six eyes of 13 patients affected by unilateral idiopathic ERM were prospectively analyzed. 13 fellow eyes were used as control. The static (central retinal artery and vein equivalents) and dynamic (after flicker light stimulus) DVA analysis was performed at baseline (1 day before surgery) and 6 months after vitrectomy.
The static DVA analysis did not highlight any significant change between investigational eyes and controls at baseline and 6 months after surgery. The DVA dynamic analysis showed similar arterial flicker response between cases and controls at baseline (p = 0.3396), but disclosed a significant reduction of the arterial flicker response after surgery in the study eyes compared to fellow eyes (p = 0.0024). No significant changes were appreciated in the venous flicker response after surgery between cases and controls, both at baseline (p = 0.3450) and at the follow-up examination (p = 0.4214).
The physiological flicker-induced vasoconstriction is reduced after vitrectomy in arteries. The oxygen saturation change occurring after vitrectomy might have a role in the vascular tone modification.
使用动态血管分析仪（DVA）研究特发性视网膜前膜（ERM）玻璃体切除术后可能发生的视网膜血管变化。
对13例单侧特发性ERM患者的26只眼进行前瞻性分析。13只对侧眼作为对照。在基线（手术前1天）和玻璃体切除术后6个月进行静态（视网膜中央动脉和静脉等效物）和动态（闪烁光刺激后）DVA分析。
静态DVA分析未显示研究眼与对照眼在基线和术后6个月之间有任何显著变化。DVA动态分析显示，病例组和对照组在基线时动脉闪烁反应相似（p = 0.3396），但与对侧眼相比，研究眼术后动脉闪烁反应显著降低（p = 0.0024）。病例组和对照组术后静脉闪烁反应在基线（p = 0.3450）和随访检查时（p = 0.4214）均无显著变化。
玻璃体切除术后动脉中由生理性闪烁引起的血管收缩减弱。玻璃体切除术后发生的氧饱和度变化可能在血管张力改变中起作用。
