Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, 266071, China.
Neurosci Bull. 2017 Oct;33(5):568-575. doi: 10.1007/s12264-017-0123-4. Epub 2017 Mar 23.
The application of neurotrophic factors (NTFs) is a promising therapeutic strategy for neurodegenerative disorders such as Parkinson's disease (PD). Many NTFs have been reported to enhance the survival, regeneration, and differentiation of neurons and to induce synaptic plasticity. However, because of their potential side-effects and low efficacy after clinical administration, more potent treatments for neurodegenerative disorders are being sought. Cerebral dopamine neurotrophic factor (CDNF), a newly-identified NTF homologous to mesencephalic astrocyte-derived NTF, is structurally and functionally different from other NTFs, providing new hope especially for PD patients. In various animal models of PD, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, neuroinflammation, and apoptosis. Recent progress in all facets of CDNF research has enabled researchers to better understand its beneficial effects in the treatment of PD.
神经营养因子 (NTFs) 的应用是治疗帕金森病 (PD) 等神经退行性疾病的有前途的治疗策略。许多 NTF 已被报道可增强神经元的存活、再生和分化，并诱导突触可塑性。然而，由于其在临床给药后的潜在副作用和低疗效，正在寻找更有效的神经退行性疾病治疗方法。脑源性神经营养因子 (CDNF) 是一种新鉴定的与中脑星形胶质细胞衍生的神经营养因子同源的 NTF，在结构和功能上与其他 NTF 不同，为 PD 患者提供了新的希望。在 PD 的各种动物模型中，CDNF 能够有效保护和修复多巴胺能神经元，并抑制内质网应激、神经炎症和细胞凋亡。CDNF 研究各个方面的最新进展使研究人员能够更好地了解其在 PD 治疗中的有益作用。
