• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

五味子甲素通过 STAT 信号通路上调抗病毒干扰素反应抑制登革病毒复制。

Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway.

机构信息

Department of Chinese Medicine, Chi Mei Medical Center, Tainan 71004, Taiwan.

Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan.

出版信息

Sci Rep. 2017 Mar 24;7:45171. doi: 10.1038/srep45171.

DOI:10.1038/srep45171
PMID:28338050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5364541/
Abstract

Dengue virus (DENV) infects 400 million people worldwide annually. Infection of more than one serotype of DENV highly corresponds to dengue hemorrhagic fever and dengue shock syndrome, which are the leading causes of high mortality. Due to lack of effective vaccines and unavailable therapies against DENV, discovery of anti-DENV agents is urgently needed. We first characterize that Schisandrin A can inhibit the replication of four serotypes of DENV in a concentration- and time-dependent manner, with an effective half-maximal effective concentration 50% (EC) value of 28.1 ± 0.42 μM against DENV serotype type 2 without significant cytotoxicity. Furthermore, schisandrin A can effectively protect mice from DENV infection by reducing disease symptoms and mortality of DENV-infected mice. We demonstrate that STAT1/2-mediated antiviral interferon responses contribute to the action of schisandrin A against DENV replication. Schisandrin A represents a potential antiviral agent to block DENV replication in vitro and in vivo. In conclusion, stimulation of STAT1/2-mediated antiviral interferon responses is a promising strategy to develop antiviral drug.

摘要

登革热病毒（DENV）每年感染全球 4 亿人。感染一种以上的 DENV 血清型与登革出血热和登革休克综合征高度相关，这是导致高死亡率的主要原因。由于缺乏有效的 DENV 疫苗和治疗方法，迫切需要发现抗 DENV 药物。我们首先描述了五味子甲素能够以浓度和时间依赖的方式抑制四种血清型 DENV 的复制，对 DENV 血清型 2 的有效半数最大有效浓度 50%（EC）值为 28.1±0.42μM，而对细胞无明显细胞毒性。此外，五味子甲素能有效保护 DENV 感染的小鼠，减轻 DENV 感染小鼠的症状和死亡率。我们证明 STAT1/2 介导的抗病毒干扰素反应有助于五味子甲素对抗 DENV 复制的作用。五味子甲素是一种有潜力的抗病毒药物，可在体外和体内阻断 DENV 的复制。总之，刺激 STAT1/2 介导的抗病毒干扰素反应是开发抗病毒药物的一种有前途的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/54bb5d735eaf/srep45171-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/156142ae7cb0/srep45171-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/c203eb14350b/srep45171-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/d3650210dea7/srep45171-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/c0640eaad509/srep45171-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/b8b2aba22c5b/srep45171-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/054782325488/srep45171-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/4f40ba585926/srep45171-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/54bb5d735eaf/srep45171-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/156142ae7cb0/srep45171-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/c203eb14350b/srep45171-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/d3650210dea7/srep45171-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/c0640eaad509/srep45171-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/b8b2aba22c5b/srep45171-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/054782325488/srep45171-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/4f40ba585926/srep45171-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/5364541/54bb5d735eaf/srep45171-f8.jpg

相似文献

1
Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway.五味子甲素通过 STAT 信号通路上调抗病毒干扰素反应抑制登革病毒复制。
Sci Rep. 2017 Mar 24;7:45171. doi: 10.1038/srep45171.
2
Celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses.雷公藤红素通过上调I型干扰素及下游干扰素刺激反应来抑制登革病毒复制。
Antiviral Res. 2017 Jan;137:49-57. doi: 10.1016/j.antiviral.2016.11.010. Epub 2016 Nov 12.
3
Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1.颅通定通过诱导血红素加氧酶-1抑制登革热病毒复制。
Virulence. 2018 Jan 1;9(1):588-603. doi: 10.1080/21505594.2017.1421893.
4
(E)-Guggulsterone Inhibits Dengue Virus Replication by Upregulating Antiviral Interferon Responses through the Induction of Heme Oxygenase-1 Expression.(E)-Guggulsterone 通过诱导血红素加氧酶-1 的表达上调抗病毒干扰素反应抑制登革病毒复制。
Viruses. 2021 Apr 20;13(4):712. doi: 10.3390/v13040712.
5
Avocado (Persea americana) fruit extract (2R,4R)-1,2,4-trihydroxyheptadec-16-yne inhibits dengue virus replication via upregulation of NF-κB-dependent induction of antiviral interferon responses.鳄梨（Persea americana）果提取物（2R,4R）-1,2,4-三羟基十七烷-16-炔通过上调 NF-κB 依赖性诱导抗病毒干扰素反应来抑制登革热病毒复制。
Sci Rep. 2019 Jan 23;9(1):423. doi: 10.1038/s41598-018-36714-4.
6
MicroRNA-155 inhibits dengue virus replication by inducing heme oxygenase-1-mediated antiviral interferon responses.MicroRNA-155 通过诱导血红素加氧酶-1 介导的抗病毒干扰素反应抑制登革病毒复制。
FASEB J. 2020 Jun;34(6):7283-7294. doi: 10.1096/fj.201902878R. Epub 2020 Apr 11.
7
Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication.登革病毒靶向 Nrf2 介导的 NS2B3 降解，导致增强的氧化应激和病毒复制。
J Virol. 2020 Nov 23;94(24). doi: 10.1128/JVI.01551-20.
8
Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway.褪黑素通过 Sirtuin 1 介导的干扰素途径抑制登革病毒感染。
Viruses. 2021 Apr 11;13(4):659. doi: 10.3390/v13040659.
9
Narasin, a novel antiviral compound that blocks dengue virus protein expression.那拉菌素，一种能阻断登革病毒蛋白表达的新型抗病毒化合物。
Antivir Ther. 2011;16(8):1203-18. doi: 10.3851/IMP1884.
10
AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78.AR-12通过下调PI3K/AKT和GRP78来抑制登革病毒复制。
Antiviral Res. 2017 Jun;142:158-168. doi: 10.1016/j.antiviral.2017.02.015. Epub 2017 Feb 24.

引用本文的文献

1
A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment.五味子木脂素的综合综述：药代动力学、药理机制及疾病防治的未来前景
Chin Med. 2025 Apr 9;20(1):47. doi: 10.1186/s13020-025-01096-z.
2
Assessing Traditional Chinese Medicines for Anti-Dengue Using a National Health Insurance Research Database and Bioassays.利用全民健康保险研究数据库和生物测定法评估中药抗登革热的效果。
Food Sci Nutr. 2025 Feb 28;13(3):e70009. doi: 10.1002/fsn3.70009. eCollection 2025 Mar.
3
The Current Landscape of Bioactive Molecules against DENV: A Systematic Review.

本文引用的文献

1
High Anti-Dengue Virus Activity of the OAS Gene Family Is Associated With Increased Severity of Dengue.OAS基因家族的高抗登革病毒活性与登革热严重程度增加有关。
J Infect Dis. 2015 Dec 15;212(12):2011-20. doi: 10.1093/infdis/jiv321. Epub 2015 Jun 10.
2
Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant.登革病毒非结构蛋白通过阻断TBK1/IRF3磷酸化抑制RIG-I/MAVS信号传导：登革病毒1型NS4A是一种独特的干扰素调节毒力决定因素。
mBio. 2015 May 12;6(3):e00553-15. doi: 10.1128/mBio.00553-15.
3
From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors.
抗登革病毒生物活性分子的现状：一项系统综述
Evid Based Complement Alternat Med. 2023 Feb 10;2023:2236210. doi: 10.1155/2023/2236210. eCollection 2023.
4
Potential protective benefits of Schisandrin B against severe acute hepatitis in children during the COVID-19 pandemic based on a network pharmacology analysis.基于网络药理学分析探讨五味子醇甲对新冠疫情期间儿童重症急性肝炎的潜在保护作用
Front Pharmacol. 2022 Aug 11;13:969709. doi: 10.3389/fphar.2022.969709. eCollection 2022.
5
Therapeutic Potential of Medicinal Plants against Dengue Infection: A Mechanistic Viewpoint.药用植物抗登革热感染的治疗潜力：一个机制性观点
ACS Omega. 2022 Jul 6;7(28):24048-24065. doi: 10.1021/acsomega.2c00625. eCollection 2022 Jul 19.
6
Traditional Knowledge to Contemporary Medication in the Treatment of Infectious Disease Dengue: A Review.传统知识在登革热传染病治疗中的当代应用：综述
Front Pharmacol. 2022 Mar 14;13:750494. doi: 10.3389/fphar.2022.750494. eCollection 2022.
7
INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 Phosphorylation.INMI1 寨卡病毒 NS4B 通过抑制 STAT1 磷酸化拮抗干扰素信号通路。
Viruses. 2021 Dec 6;13(12):2448. doi: 10.3390/v13122448.
8
Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2.寨卡病毒 NS2A 通过降解 STAT1 和 STAT2 抑制干扰素信号转导。
Virulence. 2021 Dec;12(1):1580-1596. doi: 10.1080/21505594.2021.1935613.
9
Dibenzocyclooctadiene Lignans in Plant Parts and Fermented Beverages of .植物各部分及发酵饮料中的二苯并环辛二烯木脂素 。 （原文不完整，翻译到这里会发现句子成分残缺）
Plants (Basel). 2021 Feb 13;10(2):361. doi: 10.3390/plants10020361.
10
Medicinal plants: Treasure for antiviral drug discovery.药用植物：抗病毒药物发现的宝库。
Phytother Res. 2021 Jul;35(7):3447-3483. doi: 10.1002/ptr.7039. Epub 2021 Feb 16.
从传统中药植物五味子中提取出对耐非核苷类抑制剂的HIV-1逆转录酶有效的新支架。
J Microbiol. 2015 Apr;53(4):288-93. doi: 10.1007/s12275-015-4652-0. Epub 2015 Mar 4.
4
Characterization of the activity of 2'-C-methylcytidine against dengue virus replication.2'-C-甲基胞苷抗登革病毒复制活性的表征
Antiviral Res. 2015 Apr;116:1-9. doi: 10.1016/j.antiviral.2015.01.002. Epub 2015 Jan 19.
5
Effect of Schisandra chinensis on interleukins, glucose metabolism, and pituitary-adrenal and gonadal axis in rats under strenuous swimming exercise.五味子对剧烈游泳运动大鼠白细胞介素、糖代谢及垂体-肾上腺和性腺轴的影响
Chin J Integr Med. 2015 Jan;21(1):43-8. doi: 10.1007/s11655-014-1765-y. Epub 2014 Aug 20.
6
Antiasthmatic effects of schizandrae fructus extract in mice with asthma.五味子提取物对哮喘小鼠的抗哮喘作用。
Pharmacogn Mag. 2014 Jan;10(Suppl 1):S80-5. doi: 10.4103/0973-1296.127348.
7
First experimental in vivo model of enhanced dengue disease severity through maternally acquired heterotypic dengue antibodies.通过母体获得的异型登革热抗体增强登革热疾病严重程度的首个体内实验模型。
PLoS Pathog. 2014 Apr 3;10(4):e1004031. doi: 10.1371/journal.ppat.1004031. eCollection 2014 Apr.
8
STAT2 and IRF9: Beyond ISGF3.信号转导和转录激活因子2与干扰素调节因子9：超越干扰素刺激基因因子3
JAKSTAT. 2013 Oct 1;2(4):e27521. doi: 10.4161/jkst.27521. Epub 2013 Dec 18.
9
Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.穿心莲内酯通过p38丝裂原活化蛋白激酶/核因子E2相关因子2（p38 MAPK/Nrf2）信号通路上调血红素加氧酶-1，从而发挥抗丙型肝炎病毒的活性。
Br J Pharmacol. 2014 Jan;171(1):237-52. doi: 10.1111/bph.12440.
10
The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus.IRF-3 和 IRF-7 在抗病毒固有免疫防御登革热病毒中的作用。
J Immunol. 2013 Oct 15;191(8):4194-201. doi: 10.4049/jimmunol.1300799. Epub 2013 Sep 16.