Mortada Boushra, Matar Tamara Abou, Sakaya Aya, Atallah Hala, Kara Ali Zeinab, Karam Pierre, Hmadeh Mohamad
Chemistry Department, American University of Beirut , P.O.Box 11-0236, Riad El-Solh, 1107 2020 Beirut, Lebanon.
Inorg Chem. 2017 Apr 17;56(8):4740-4745. doi: 10.1021/acs.inorgchem.7b00429. Epub 2017 Mar 24.
Metal-organic frameworks (MOFs) have emerged as an important class of hybrid organic-inorganic materials. One of the reasons they have gained remarkable attention is attributed to the possibility of altering them by postsynthetic modification, thereby providing access to new and novel advanced materials. MOFs have been applied in catalysis, gas storage, gas separation, chemical sensing, and drug delivery. However, their bactericidal use has rarely been explored. Herein, we developed a two-step process for the synthesis of zirconium-based MOFs metalated with silver cations as a potent antibacterial agent. The obtained products were thoroughly characterized by powder X-ray diffraction, scanning electron microscopy, UV-visible, IR, thermogravimetric, and Brunauer-Emmett-Teller analyses. Their potency was evaluated against E. coli with a reported minimal inhibitory concentration and minimal bactericidal concentration of as low as 6.5 μg/mL of silver content. Besides the novelty of the system, the advantage of this strategy is that the MOFs could be potentially regenerated and remetalated after each antibacterial test, unlike previously reported frameworks, which involved the destruction of the framework.
金属有机框架材料（MOFs）已成为一类重要的有机-无机杂化材料。它们受到广泛关注的原因之一是可以通过后合成修饰对其进行改变，从而获得新型的先进材料。MOFs已应用于催化、气体存储、气体分离、化学传感和药物递送等领域。然而，它们的杀菌用途很少被探索。在此，我们开发了一种两步法来合成用银阳离子金属化的锆基金属有机框架材料，作为一种有效的抗菌剂。通过粉末X射线衍射、扫描电子显微镜、紫外可见光谱、红外光谱、热重分析和布鲁诺尔-埃米特-泰勒分析对所得产物进行了全面表征。以大肠杆菌为测试对象评估了它们的效力，报告的最低抑菌浓度和最低杀菌浓度低至银含量6.5μg/mL。除了该体系的新颖性之外，该策略的优点是与之前报道的涉及框架破坏的框架不同，MOFs在每次抗菌测试后都有可能再生并重新金属化。
