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头孢他啶-阿维巴坦:用于治疗复杂性尿路感染的新型抗菌组合。

Ceftazidime-avibactam: novel antimicrobial combination for the treatment of complicated urinary tract infections.

作者信息

Alidjanov Jakhongir F, Fritzenwanker Moritz, Hoffman Ivan, Wagenlehner Florian M

机构信息

Clinic & Policlinic for Urology, Pediatric Urology & Andrology, Justus-Liebig University, Giessen, Germany.

Outpatient Department, JSC "Republican Specialized Center of Urology", Tashkent, Uzbekistan.

出版信息

Future Microbiol. 2017 Jun;12:655-670. doi: 10.2217/fmb-2016-0213. Epub 2017 Mar 24.

DOI:10.2217/fmb-2016-0213
PMID:28338347
Abstract

Ceftazidime-avibactam is a combination of a third-generation cephalosporin and a novel non-beta-lactam beta-lactamase inhibitor. This combination was recently recommended for the treatment of complicated urinary tract infections, including acute pyelonephritis, in adults with limited or no alternative treatment options. The current review is aimed to determine activity, efficacy and safety of ceftazidime-avibactam in the treatment of patients with complicated urinary tract infections.

摘要

头孢他啶-阿维巴坦是第三代头孢菌素与新型非β-内酰胺类β-内酰胺酶抑制剂的组合。最近,对于治疗选择有限或没有其他选择的成人复杂性尿路感染,包括急性肾盂肾炎,推荐使用这种组合。本综述旨在确定头孢他啶-阿维巴坦治疗复杂性尿路感染患者的活性、疗效和安全性。

相似文献

1
Ceftazidime-avibactam: novel antimicrobial combination for the treatment of complicated urinary tract infections.头孢他啶-阿维巴坦:用于治疗复杂性尿路感染的新型抗菌组合。
Future Microbiol. 2017 Jun;12:655-670. doi: 10.2217/fmb-2016-0213. Epub 2017 Mar 24.
2
Ceftazidime-avibactam for the treatment of complicated urinary tract infections and complicated intra-abdominal infections.头孢他啶-阿维巴坦用于治疗复杂性尿路感染和复杂性腹腔内感染。
Expert Rev Clin Pharmacol. 2015;8(6):691-707. doi: 10.1586/17512433.2015.1090874. Epub 2015 Sep 30.
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Focus on ceftazidime-avibactam for optimizing outcomes in complicated intra-abdominal and urinary tract infections.关注头孢他啶-阿维巴坦以优化复杂性腹腔内感染和尿路感染的治疗效果。
Expert Opin Investig Drugs. 2015;24(9):1261-73. doi: 10.1517/13543784.2015.1062873. Epub 2015 Jul 6.
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Ceftazidime/avibactam: a novel cephalosporin/nonbeta-lactam beta-lactamase inhibitor for the treatment of complicated urinary tract infections and complicated intra-abdominal infections.头孢他啶/阿维巴坦:一种用于治疗复杂性尿路感染和复杂性腹腔内感染的新型头孢菌素/非β-内酰胺类β-内酰胺酶抑制剂。
Drug Des Devel Ther. 2016 Jul 26;10:2379-86. doi: 10.2147/DDDT.S110946. eCollection 2016.
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Ceftazidime-avibactam or best available therapy in patients with ceftazidime-resistant Enterobacteriaceae and Pseudomonas aeruginosa complicated urinary tract infections or complicated intra-abdominal infections (REPRISE): a randomised, pathogen-directed, phase 3 study.头孢他啶-阿维巴坦或最佳现有治疗在头孢他啶耐药肠杆菌科和铜绿假单胞菌引起的复杂性尿路感染或复杂性腹腔内感染患者中的应用(REPRISE):一项随机、针对病原体的 3 期研究。
Lancet Infect Dis. 2016 Jun;16(6):661-673. doi: 10.1016/S1473-3099(16)30004-4. Epub 2016 Apr 20.
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What is the role of the new β-lactam/β-lactamase inhibitors ceftolozane/tazobactam and ceftazidime/avibactam?新型β-内酰胺/β-内酰胺酶抑制剂头孢洛扎/他唑巴坦和头孢他啶/阿维巴坦的作用是什么?
Expert Rev Anti Infect Ther. 2016 Oct;14(10):875-8. doi: 10.1080/14787210.2016.1233060.
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A randomised, double-blind, phase 3 study comparing the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem for complicated intra-abdominal infections in hospitalised adults in Asia.一项在亚洲住院成人中比较头孢他啶/阿维巴坦加甲硝唑与美罗培南治疗复杂性腹腔内感染的疗效和安全性的随机、双盲、3 期研究。
Int J Antimicrob Agents. 2017 May;49(5):579-588. doi: 10.1016/j.ijantimicag.2017.01.010. Epub 2017 Mar 29.
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In vitro activity of ceftazidime/avibactam against urinary isolates from patients in a Phase 3 clinical trial programme for the treatment of complicated urinary tract infections.头孢他啶/阿维巴坦对治疗复杂性尿路感染3期临床试验项目中患者尿液分离株的体外活性。
J Antimicrob Chemother. 2017 May 1;72(5):1396-1399. doi: 10.1093/jac/dkw561.
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Ceftazidime/Avibactam: A New Antibiotic for Gram-Negative Infections.头孢他啶/阿维巴坦:一种用于革兰氏阴性菌感染的新型抗生素。
Consult Pharm. 2015 Dec;30(12):695-705. doi: 10.4140/TCP.n.2015.695.
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The β-Lactams Strike Back: Ceftazidime-Avibactam.β-内酰胺类药物卷土重来:头孢他啶-阿维巴坦
Pharmacotherapy. 2015 Aug;35(8):755-70. doi: 10.1002/phar.1622.

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