Giordano Lisa, Akinyede Oyinade, Bhatt Nidhi, Dighe Dipti, Iqbal Asneha
1 Department of Pediatrics, Cook County Health and Hospitals System , Chicago, Illinois.
2 Department of Pediatrics, University of Illinois Hospital and Health Sciences System , Chicago, Illinois.
J Adolesc Young Adult Oncol. 2017 Sep;6(3):494-498. doi: 10.1089/jayao.2016.0094. Epub 2017 Mar 24.
Intrathecal methotrexate (IT MTX) and high-dose intravenous methotrexate (HD MTX) are important components of treatment in high-risk acute leukemia. We describe five Hispanic adolescents with high-risk acute leukemia at our institution who experienced MTX-induced neurotoxicity. All patients were eventually rechallenged with MTX. Two of the five patients had a second episode of neurotoxicity, but all patients recovered. Further studies should be performed to determine whether Hispanic patients are more susceptible to MTX neurotoxicity.
鞘内注射甲氨蝶呤（IT MTX）和大剂量静脉注射甲氨蝶呤（HD MTX）是高危急性白血病治疗的重要组成部分。我们描述了我院5名患有高危急性白血病的西班牙裔青少年，他们经历了甲氨蝶呤诱导的神经毒性。所有患者最终都再次接受了甲氨蝶呤治疗。5名患者中有2名出现了第二次神经毒性发作，但所有患者均康复。应进行进一步研究以确定西班牙裔患者是否更易发生甲氨蝶呤神经毒性。
