Lobos-Urbina Diego, Kittsteiner-Manubens Lucas, Peña José
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Email:
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Medwave. 2017 Mar 21;17(Suppl1):e6871. doi: 10.5867/medwave.2017.6871.
Patients with brain tumors primary or metastatic- have an increased risk of presenting seizures during the course of their disease. So, prophylactic antiepileptic drugs have been proposed. However, the effects of this intervention are not yet clear. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. We identified 12 systematic reviews including 80 studies overall. Twelve corresponded to randomized trials, but only two answered the question of interest. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE method. We concluded primary prevention with antiepileptic drugs might not reduce the risk of seizures, and it is associated to frequent adverse effects.
患有脑肿瘤（原发性或转移性）的患者在其疾病过程中出现癫痫发作的风险增加。因此，有人提出使用预防性抗癫痫药物。然而，这种干预措施的效果尚不清楚。为了回答这个问题，我们在由多个数据库筛选维护的Epistemonikos数据库中进行了检索。我们确定了12项系统评价，总共包括80项研究。其中12项对应随机试验，但只有两项回答了感兴趣的问题。我们提取数据，进行荟萃分析，并使用GRADE方法生成结果总结表。我们得出结论，使用抗癫痫药物进行一级预防可能不会降低癫痫发作的风险，而且会带来频繁的不良反应。
