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The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1.

作者信息

Berberich Ingolf, Hildeman David A

机构信息

Institute for Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany.

UC Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

出版信息

Cell Death Differ. 2017 Apr;24(4):572-574. doi: 10.1038/cdd.2017.25. Epub 2017 Mar 24.

DOI:10.1038/cdd.2017.25
PMID:28338657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5384030/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e75/5384030/61b012dad2e9/cdd201725f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e75/5384030/61b012dad2e9/cdd201725f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e75/5384030/61b012dad2e9/cdd201725f1.jpg

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本文引用的文献

1
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies.BCL-2 三十年：将细胞死亡发现转化为新型癌症疗法。
Nat Rev Cancer. 2016 Feb;16(2):99-109. doi: 10.1038/nrc.2015.17.
2
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.敲低抗凋亡Bcl-2家族成员A1/Bfl-1可保护小鼠免受过敏反应。
J Immunol. 2015 Feb 1;194(3):1316-22. doi: 10.4049/jimmunol.1400637. Epub 2014 Dec 29.
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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
在炎症性口面疼痛模型中，三叉神经节中血激肽-1 基因表达上调：在外周致敏中的潜在作用。
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IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation.IL-1 信号转导介导宫内炎症和绒毛蜕膜中性粒细胞募集和激活。
JCI Insight. 2018 Mar 22;3(6):98306. doi: 10.1172/jci.insight.98306.
BCL-2 蛋白家族对细胞凋亡的调控：对生理学和治疗的意义。
Nat Rev Mol Cell Biol. 2014 Jan;15(1):49-63. doi: 10.1038/nrm3722.
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Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.体内 RNAi 靶向抗凋亡 A1/Bfl-1 揭示了其在小鼠白细胞发育中的多种作用。
Blood. 2012 Jun 21;119(25):6032-42. doi: 10.1182/blood-2011-12-399089. Epub 2012 May 11.
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A1/Bfl-1 in leukocyte development and cell death.A1/Bfl-1 在白细胞发育和细胞死亡中的作用。
Exp Cell Res. 2012 Jul 1;318(11):1291-303. doi: 10.1016/j.yexcr.2012.01.021. Epub 2012 Feb 4.
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Role of Bim in regulating CD8+ T-cell responses during chronic viral infection.Bim在慢性病毒感染过程中调节CD8 + T细胞反应中的作用。
J Virol. 2006 Sep;80(17):8627-38. doi: 10.1128/JVI.00855-06.
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Deficiency in the anti-apoptotic protein A1-a results in a diminished acute inflammatory response.抗凋亡蛋白A1-a的缺乏导致急性炎症反应减弱。
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