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不复苏医嘱与髋部骨折患者的早期死亡。

Do-not-resuscitate orders and early mortality in hip fracture patients.

机构信息

OLVG Location West-Surgery, Amsterdam, The Netherlands.

AMC-Orthopaedic Surgery, Amsterdam, The Netherlands.

出版信息

Age Ageing. 2017 Nov 1;46(6):946-951. doi: 10.1093/ageing/afx027.

Abstract

BACKGROUND

factors affecting mortality after hip fracture surgery have been studied extensively. It has been suggested that do-not-resuscitate (DNR) orders are associated with higher mortality in surgical patients due to less aggressive treatment. However, the effect of DNR orders on mortality in hip fracture patients is unknown. The objective of this study was to investigate the effect of DNR orders on early mortality after hip fracture surgery.

METHODS

all patients undergoing hip fracture surgery between 2004 and 2015 were included in this retrospective study. Patient characteristics such as age, comorbidities and fracture type were collected, as were resuscitation preferences. Multivariable logistic regression analysis was performed to identify independent risk factors for early mortality.

RESULTS

a total of 1,803 patients were analysed, of which 823 (45.6%) had DNR orders. DNR patients were older, more often female, had lower haemoglobin levels and more comorbidities when compared with non-DNR patients. The unadjusted effect of DNR orders on mortality was high (OR: 2.39; P < 0.001). Multivariable analysis demonstrated that increased age, male gender, higher American Society of Anesthesiologists score, low admission haemoglobin, living in an institution, high Charlson Comorbidity Index and delay to surgery were associated with increased early mortality after hip fracture surgery. There was no independent effect of DNR orders on mortality after adjustment for these variables (P = 0.735).

CONCLUSIONS

DNR patients have higher mortality rates due to poor health status. Resuscitation preferences on their own are not associated with early mortality after hip fracture surgery.

摘要

背景

影响髋部骨折手术后死亡率的因素已被广泛研究。有人认为,由于治疗不积极,对于手术患者来说,不复苏(DNR)医嘱与更高的死亡率有关。然而,DNR 医嘱对髋部骨折患者死亡率的影响尚不清楚。本研究旨在探讨 DNR 医嘱对髋部骨折手术后早期死亡率的影响。

方法

本回顾性研究纳入了 2004 年至 2015 年间接受髋部骨折手术的所有患者。收集了患者特征,如年龄、合并症和骨折类型,以及复苏偏好。采用多变量逻辑回归分析确定早期死亡率的独立危险因素。

结果

共分析了 1803 例患者,其中 823 例(45.6%)有 DNR 医嘱。与非 DNR 患者相比,DNR 患者年龄更大,女性更多,血红蛋白水平更低,合并症更多。DNR 医嘱对死亡率的未调整影响较大(OR:2.39;P<0.001)。多变量分析表明,年龄增加、男性、美国麻醉医师协会评分较高、入院时血红蛋白较低、居住在机构中、较高的 Charlson 合并症指数和手术延迟与髋部骨折手术后早期死亡率增加相关。在调整这些变量后,DNR 医嘱对死亡率没有独立影响(P=0.735)。

结论

由于健康状况不佳,DNR 患者的死亡率更高。复苏偏好本身与髋部骨折手术后的早期死亡率无关。

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