Park Bohyun, Lee Hye Ah, Lee Sung Hee, Park Bo Mi, Park Eun Ae, Kim Hae Soon, Cho Su Jin, Park Hyesook
Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea.
Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, South Korea.
Am J Hypertens. 2017 Jul 1;30(7):713-718. doi: 10.1093/ajh/hpx037.
Recent studies suggest that high levels of serum uric acid of very early life are a result of the in-utero environment and may lead to elevated blood pressure (BP) in adulthood. However, serum uric acid levels can change throughout life. We investigated the effect of serum uric acid levels in childhood on the BP tracking and analysed BP according to changes in serum uric acid levels in early life.
A total of 449 children from the Ewha Birth and Growth Cohort study underwent at least 2 follow-up examinations. Data were collected across 3 check-up cycles. Serum uric acid levels, BP, and anthropometric characteristics were assessed at 3, 5, and 7 years of age.
Children with a serum uric acid level higher than the median values had significantly increased systolic BP (SBP) and diastolic BP at 3 years of age. Baseline serum uric acid levels measured at 3 years of age, significantly affected subsequent BP in the sex and body mass index adjusted longitudinal data analysis (P < 0.05). Considering the changing pattern of serum uric acid over time, subjects with high uric acid levels at both 3 and 5 years of age had the highest SBP at 7 years of age.
These findings suggest the importance of maintaining an adequate level of serum uric acids from the early life. Appropriate monitoring and intervention of uric acid levels in a high-risk group can reduce the risk of a future increased BP.
近期研究表明，生命早期血清尿酸水平升高是子宫内环境所致，可能导致成年后血压升高。然而，血清尿酸水平在一生中会发生变化。我们研究了儿童期血清尿酸水平对血压轨迹的影响，并根据生命早期血清尿酸水平的变化分析了血压情况。
梨花出生与生长队列研究中的449名儿童至少接受了2次随访检查。数据收集跨越3个检查周期。在3岁、5岁和7岁时评估血清尿酸水平、血压和人体测量特征。
血清尿酸水平高于中位数的儿童在3岁时收缩压（SBP）和舒张压显著升高。在按性别和体重指数调整的纵向数据分析中，3岁时测得的基线血清尿酸水平对随后的血压有显著影响（P<0.05）。考虑到血清尿酸随时间的变化模式，3岁和5岁时尿酸水平均较高的受试者在7岁时SBP最高。
这些发现表明从生命早期就维持适当血清尿酸水平的重要性。对高危人群的尿酸水平进行适当监测和干预可降低未来血压升高的风险。
