Gaudio Agostino, Fiore Valerio, Rapisarda Rosario, Sidoti Maria Helga, Xourafa Anastasia, Catalano Antonino, Tringali Giovanni, Zanoli Luca, Signorelli Salvatore Santo, Fiore Carmelo Erio
Department of Clinical and Experimental Medicine, University of Catania, I-95123 Catania, Italy.
Department of Clinical and Experimental Medicine, University of Messina, I-98125 Messina, Italy.
Mol Med Rep. 2017 May;15(5):3420-3424. doi: 10.3892/mmr.2017.6390. Epub 2017 Mar 24.
Osteoporosis and cardiovascular disease are worldwide public health issues. Recent evidence indicates a possible role of the canonical Wnt/β-catenin signalling pathway as a common mediator between these two diseases. The aim of the present study was to investigate the relationship between serum concentrations of sclerostin and Dkk1, two extracellular inhibitors of Wnt/β-catenin signalling, with carotid intima-media thickness (CIMT) and with arterial stiffness, evaluated by measuring the pulse wave velocity (PWV) in an ambulatory population of adults. To this aim, 67 subjects were recruited in the 'Atherosclerosis and osteoporosis: identification of common pathogenetic factors' investigation. Serum sclerostin levels correlated positively with CIMT (r=0.314, p=0.03) and inversely with the augmentation index, a marker of arterial stiffness (r=-0.286, p<0.05), whereas Dkk1 did not. Moreover, in a multivariate linear regression model, sclerostin [β -0.1472; p=0.0023; standard error (SE)=0.04620] was an independent predictor of PWV in the study subjects. Our study shows that, following adjustment for confounders, sclerostin is an independent predictor of arterial stiffness in an ambulatory population, whereas Dkk1 is not.
骨质疏松症和心血管疾病是全球性的公共卫生问题。最近的证据表明，经典的Wnt/β-连环蛋白信号通路可能是这两种疾病之间的共同介导因素。本研究的目的是调查硬化素和Dkk1（Wnt/β-连环蛋白信号的两种细胞外抑制剂）的血清浓度与颈动脉内膜中层厚度（CIMT）以及与动脉僵硬度之间的关系，动脉僵硬度通过测量成年门诊人群的脉搏波速度（PWV）进行评估。为此，在“动脉粥样硬化与骨质疏松症：共同致病因素的识别”调查中招募了67名受试者。血清硬化素水平与CIMT呈正相关（r = 0.314，p = 0.03），与作为动脉僵硬度标志物的增强指数呈负相关（r = -0.286，p < 0.05），而Dkk1则不然。此外，在多变量线性回归模型中，硬化素[β -0.1472；p = 0.0023；标准误差（SE）= 0.04620]是研究对象中PWV的独立预测因子。我们的研究表明，在对混杂因素进行校正后，硬化素是门诊人群动脉僵硬度的独立预测因子，而Dkk1则不是。
