赖诺普利与硝苯地平：在血压正常者中无急性相互作用。
Lisinopril and nifedipine: no acute interaction in normotensives.
作者信息
Lees K R, Reid J L
机构信息
University Department of Materia Medica, Stobhill General Hospital, Glasgow.
出版信息
Br J Clin Pharmacol. 1988 Mar;25(3):307-13. doi: 10.1111/j.1365-2125.1988.tb03308.x.
Abstract
- A double-blind, four period crossover study was undertaken to test for an interaction between single oral doses of nifedipine retard (20 mg) and lisinopril (20 mg) in normal subjects. 2. Side effects with both drugs were mild and the incidence was additive. 3. Blood pressure (BP) was lowered by nifedipine for 4 h, by lisinopril for 48 h and the combination showed simply additive effects. Standing heart rate was higher after the combination than after single treatment. 4. Plasma angiotensin converting enzyme (ACE) and renin activity (PRA), aldosterone, noradrenaline and adrenaline levels showed no evidence of an interaction. 5. The pharmacokinetics of lisinopril were unaltered by nifedipine and vice versa. 6. There is no evidence of a pharmacokinetic or pharmacodynamic interaction between single oral doses of nifedipine and lisinopril.
摘要
- 开展了一项双盲、四期交叉研究，以检测正常受试者单次口服缓释硝苯地平（20毫克）和赖诺普利（20毫克）之间的相互作用。2. 两种药物的副作用均较轻，且发生率具有相加性。3. 硝苯地平使血压降低4小时，赖诺普利使血压降低48小时，二者联合使用仅表现出相加效应。联合用药后立位心率高于单药治疗后。4. 血浆血管紧张素转换酶（ACE）、肾素活性（PRA）、醛固酮、去甲肾上腺素和肾上腺素水平均未显示出相互作用的迹象。5. 赖诺普利的药代动力学未受硝苯地平影响，反之亦然。6. 没有证据表明单次口服硝苯地平和赖诺普利之间存在药代动力学或药效学相互作用。
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