硝苯地平在人体中的首过代谢。
The first pass metabolism of nifedipine in man.
作者信息
Waller D G, Renwick A G, Gruchy B S, George C F
出版信息
Br J Clin Pharmacol. 1984 Dec;18(6):951-4. doi: 10.1111/j.1365-2125.1984.tb02569.x.
Abstract
Oral administration of nifedipine (20 and 30 mg tablets) to six volunteers was associated with a bioavailability of 0.43 and the presence of its nitropyridine analogue in the plasma. This metabolite was present in only trace amounts in samples taken from the same volunteers following i.v. administration of nifedipine. The peak plasma concentrations and area under the plasma concentration-time curve suggest that the nitropyridine analogue is a major, first pass, metabolite of nifedipine.
摘要
对6名志愿者口服硝苯地平（20毫克和30毫克片剂）后，其生物利用度为0.43，且血浆中存在其硝基吡啶类似物。在静脉注射硝苯地平后从相同志愿者采集的样本中，这种代谢物仅以痕量存在。血浆峰浓度和血浆浓度-时间曲线下面积表明，硝基吡啶类似物是硝苯地平的主要首过代谢物。
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本文引用的文献
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