Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park.
Hofstra Northwell School of Medicine, Hempstead, New York.
J Pediatric Infect Dis Soc. 2017 Jun 1;6(2):e4-e6. doi: 10.1093/jpids/piw078.
Infection with varicella-zoster virus (VZV) in oncology patients can result in severe disease with an increased risk of morbidity and mortality [1, 2]. Among patients on cancer chemotherapy, only nonimmune persons are considered to be susceptible to varicella [1]. We present a case of varicella in a child with leukemia that occurred despite immunity as defined by 2 doses of varicella vaccine and documentation of positive VZV immunoglobulin G titer before initiation of chemotherapy.
水痘带状疱疹病毒(VZV)感染可导致肿瘤患者发生严重疾病,增加发病率和死亡率[1,2]。在接受癌症化疗的患者中,只有非免疫者才被认为易感染水痘[1]。我们报告了一例白血病患儿发生水痘的病例,尽管该患儿已接种 2 剂水痘疫苗,并在开始化疗前检测到 VZV 免疫球蛋白 G 滴度阳性,具有免疫力,但仍发生了水痘。