Wingard J R, Chen D Y, Burns W H, Fuller D J, Braine H G, Yeager A M, Kaiser H, Burke P J, Graham M L, Santos G W
Oncology Center, Johns Hopkins Medical Institutions, Baltimore, MD.
Blood. 1988 May;71(5):1432-7.
Cytomegalovirus (CMV) infection was detected in 65 of 143 (45%) autologous bone marrow transplant (BMT) patients. CMV pneumonitis occurred in only 2% of the patients and CMV retinitis occurred in none. Infection occurred in half of the 40 initially seronegative patients and 47% of the 94 initially seropositive patients. Among initially seropositive patients, platelet recovery was slower in infected patients than in those not infected (97 v 35 days median, P = .003), and neutrophil recovery was slightly delayed in infected patients (31 days v 24 days, P = .02). Although the incidence of CMV infection was comparable in autologous and allogeneic BMT patients, CMV pneumonitis was less frequent in autologous BMT patients (2% v 12%, P less than .001). The risk for CMV pneumonitis in autologous BMT patients was comparable with that in allogeneic BMT patients without graft-v-host disease (GVHD) (2% v 6%), but significantly lower than the risk in allogeneic BMT patients with GVHD (2% v 23%, P less than .001).
在143例自体骨髓移植（BMT）患者中，65例（45%）检测到巨细胞病毒（CMV）感染。仅2%的患者发生CMV肺炎，无一例发生CMV视网膜炎。40例初始血清学阴性的患者中有半数发生感染，94例初始血清学阳性的患者中有47%发生感染。在初始血清学阳性的患者中，感染患者的血小板恢复比未感染患者慢（中位数分别为97天和35天，P = .003），感染患者的中性粒细胞恢复略有延迟（31天对24天，P = .02）。虽然自体和异基因BMT患者中CMV感染的发生率相当，但CMV肺炎在自体BMT患者中较少见（2%对12%，P小于.001）。自体BMT患者发生CMV肺炎的风险与无异基因移植物抗宿主病（GVHD）的异基因BMT患者相当（2%对6%），但显著低于有GVHD的异基因BMT患者（2%对23%，P小于.001）。
