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长期接受阿片类药物治疗的慢性非癌痛患者对阿片类药物的态度与误用/滥用风险。

Attitudes Toward Opioids and Risk of Misuse/Abuse in Patients with Chronic Noncancer Pain Receiving Long-term Opioid Therapy.

机构信息

Anesthesiology and Pain Management, CHUM Pain Center, Montreal, QC, Canada.

Departments of Pharmacology.

出版信息

Pain Med. 2018 Feb 1;19(2):319-327. doi: 10.1093/pm/pnw338.

Abstract

OBJECTIVES

To determine the attitudes of patients toward long-term opioid therapy (LtOT) and the potential risk of misuse/abuse in patients with chronic noncancer pain (CNCP).

DESIGN

Prospective, descriptive epidemiological study.

SETTING

Multidisciplinary tertiary care pain center within the Montreal University Health Center.

SUBJECTS

Patients who had had at least one visit at least one year prior to the invitation.

METHODS

We used four questionnaires: demographic questionnaire, the Drug Attitude Inventory Modified (DAI-M), the Opioid Risk Tool (ORT), and the Screening Tool for Addiction Risk (STAR). All questionnaires were administered in their validated French version.

RESULTS

Three hundred seventy patients completed questionnaires. The response rate was 79.26%. Of those who responded, 61.62% women and 38.38% men, the mean age was 57 years. The patients had been treated with LtOT for an average of 6.31 years, and the median dose per day in morphine equivalents was 48.21 mg. The DAI-M showed that 32.16% had a positive attitude toward opioids, 39.73% had a negative attitude, and 22.16% had a neutral attitude. The ORT questionnaire demonstrated that 86.2% of the patients were at low risk of abuse/misuse, 13.2% were at moderate risk, and only 0.54% were at high risk. The STAR questionnaire showed that 4.2% had a low risk of abuse/misuse.

CONCLUSIONS

Despite public opinion, patients treated with LtOT for CNCP and followed in a tertiary care pain center are at low risk for opioid misuse/abuse. We need to refine the way of prescribing opioids, should be selective with our patients, and should relive their pain adequately.

摘要

目的

确定慢性非癌痛(CNCP)患者对长期阿片类药物治疗(LtOT)的态度,以及潜在的误用/滥用风险。

设计

前瞻性描述性流行病学研究。

地点

蒙特利尔大学健康中心的多学科三级护理疼痛中心。

受试者

至少在邀请前一年有过一次就诊的患者。

方法

我们使用了四个问卷:人口统计学问卷、改良药物态度量表(DAI-M)、阿片类药物风险工具(ORT)和成瘾风险筛查工具(STAR)。所有问卷均采用其经过验证的法语版本进行管理。

结果

370 名患者完成了问卷。应答率为 79.26%。在回答者中,61.62%为女性,38.38%为男性,平均年龄为 57 岁。患者接受 LtOT 治疗的平均时间为 6.31 年,每天的吗啡等效剂量中位数为 48.21mg。DAI-M 显示,32.16%的患者对阿片类药物持积极态度,39.73%持消极态度,22.16%持中立态度。ORT 问卷显示,86.2%的患者滥用/误用风险低,13.2%风险中等,只有 0.54%风险高。STAR 问卷显示,4.2%的患者滥用/误用风险低。

结论

尽管公众舆论如此,但在三级护理疼痛中心接受 LtOT 治疗的 CNCP 患者滥用阿片类药物的风险较低。我们需要改进阿片类药物的开具方式,对患者进行选择性治疗,并充分缓解他们的疼痛。

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