五价轮状病毒疫苗（RV5）早期替代免疫程序与推荐标准免疫程序比较的开放性标签试验：安全性和免疫原性研究。
Open-Label Pilot Study to Compare the Safety and Immunogenicity of Pentavalent Rotavirus Vaccine (RV5) Administered on an Early Alternative Dosing Schedule with Those of RV5 Administered on the Recommended Standard Schedule.
机构信息
Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke Clinical Vaccine Unit, Duke University School of Medicine, Durham, North Carolina.
Department of Pediatrics, Durham, North Carolina.
出版信息
J Pediatric Infect Dis Soc. 2018 Feb 19;7(1):82-85. doi: 10.1093/jpids/pix005.
Abstract
This study compares the safety and immunogenicity of pentavalent rotavirus vaccine (RV5) administered on an alternative schedule (initiated at 2-5 weeks of age) with those of RV5 administered on the recommended standard schedule. Our findings support the future conduct of larger clinical trials to confirm the safety and efficacy of rotavirus vaccination in the neonatal period.
摘要
本研究比较了在替代方案（在 2-5 周龄时开始）下接种五价轮状病毒疫苗（RV5）与按照推荐标准方案接种 RV5 的安全性和免疫原性。我们的研究结果支持未来进行更大规模的临床试验，以确认新生儿期接种轮状病毒疫苗的安全性和有效性。
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