Effect of progestins on androgen delta4-3-ketosteroid-5alpha-A-ring reductase system in rat oral mucosa.
作者信息
Vittek J, Altman K, Rappaport S C, Gordon G G, Hagedorn J, Southren A L
出版信息
J Dent Res. 1978 Mar;57(3):511-9. doi: 10.1177/00220345780570032001.
PMID:28342
Abstract
Rat oral mucosa microsomal delta4-3-ketosteroid-5alpha-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/or 4-androstenedione in vitro, acted as a competitive inhibitor of the reduction of these substrates.
摘要
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