van Schaik B A, Geyskes G G, van der Wouw P A, van Rooij H H, Porsius A J
Department of Nephrology, University Hospital, Utrecht, The Netherlands.
Eur J Clin Pharmacol. 1988;34(1):61-5. doi: 10.1007/BF01061419.
The pharmacokinetics of lisinopril was studied after administration of single and multiple doses of 5 mg to hypertensive patients with normal and impaired renal function. In patients with severe renal failure the peak concentrations were higher, the decline in serum concentration was slower and the time to peak concentration was extended. Accumulation of lisinopril was highly correlated with the creatinine clearance. The effective half-life was doubled and tripled in patients with mild and severe renal impairment, respectively, as compared to patients with a normal renal function. Lisinopril lowered blood pressure in all three groups over 24 h. It is suggested that smaller doses of lisinopril should be administered to patients with severe renal failure.
对肾功能正常和受损的高血压患者分别单次和多次给予5毫克赖诺普利后，研究了其药代动力学。在严重肾功能衰竭患者中，峰值浓度较高，血清浓度下降较慢，达到峰值浓度的时间延长。赖诺普利的蓄积与肌酐清除率高度相关。与肾功能正常的患者相比，轻度和重度肾功能损害患者的有效半衰期分别延长了一倍和两倍。赖诺普利在24小时内降低了所有三组患者的血压。建议对严重肾功能衰竭患者给予较小剂量的赖诺普利。
