含离子脂质体诱导的递质释放变化。
Changes in transmitter release induced by ion-containing liposomes.
作者信息
Rahamimoff R, Meiri H, Erulkar S D, Barenholz Y
出版信息
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5214-6. doi: 10.1073/pnas.75.10.5214.
Abstract
The changes in quantal transmitter release induced by egg phosphatidylcholine liposomes with different internal ionic composition were examined at the frog neuromuscular junction by using conventional electrophysiological techniques. It was found that liposomes containing calcium or sodium ions increase both evoked and spontaneous transmitter release, while liposomes containing potassium do not. The results suggest that phosphatidylcholine liposomes are able to transfer their aqueous medium into the presynaptic nerve terminal.
摘要
利用传统电生理技术，在青蛙神经肌肉接头处检测了具有不同内部离子组成的卵磷脂脂质体诱导的量子递质释放变化。结果发现，含有钙离子或钠离子的脂质体可增加诱发的和自发的递质释放，而含有钾离子的脂质体则不能。这些结果表明，卵磷脂脂质体能够将其水相介质转移到突触前神经末梢中。
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