Weil J, Strom T M, Brangenberg R, Sebening W, Haufe M, Lang R E, Bidlingmaier F, Gerzer R
Department of Paediatrics, University of Munich, FRG.
Horm Res. 1987;28(1):64-70. doi: 10.1159/000180927.
In children with various forms of cardiac diseases (aged 2 months to 16 years) significantly higher plasma atrial natriuretic peptide (ANP; range 36-680, median 247 pg/ml) and cyclic 3'5'-guanosine monophosphate (cGMP; range 0.2-46, median 8.2 pmol/ml) levels were found than in control children (p less than 0.0001). In control children (aged 4 months to 17 years) plasma ANP and cGMP levels were measured in the range of 2.4-98 pg/ml and of 0.2-2.8 pmol/ml, respectively. There was a linear correlation between the two parameters in children with cardiac diseases (r = 0.62, p less than 0.01). Children with elevated mean right atrial pressure (i.e., greater than 6 mm Hg) showed significantly higher plasma ANP levels than children with normal atrial pressure (p less than 0.01). However, there was only a weak linear correlation between mean right atrial pressure and plasma ANP levels (r = 0.48, p less than 0.01). Plasma ANP levels from right atrium, pulmonary artery, left atrium and left ventricle were significantly higher than those from vena cava (p less than 0.05). Analysis of ANP-like immunoreactive material by high performance liquid chromatography suggested that alpha-ANP is the major form of circulating ANP in blood of children with cardiac diseases.
在患有各种形式心脏病的儿童（年龄在2个月至16岁之间）中，发现血浆心钠素（ANP；范围为36 - 680，中位数为247 pg/ml）和环磷酸鸟苷（cGMP；范围为0.2 - 46，中位数为8.2 pmol/ml）水平显著高于对照儿童（p < 0.0001）。在对照儿童（年龄在4个月至17岁之间）中，血浆ANP和cGMP水平分别在2.4 - 98 pg/ml和0.2 - 2.8 pmol/ml范围内测量。在患有心脏病的儿童中，这两个参数之间存在线性相关性（r = 0.62，p < 0.01）。平均右心房压力升高（即大于6 mmHg）的儿童血浆ANP水平显著高于心房压力正常的儿童（p < 0.01）。然而，平均右心房压力与血浆ANP水平之间仅存在微弱的线性相关性（r = 0.48，p < 0.01）。右心房、肺动脉、左心房和左心室的血浆ANP水平显著高于腔静脉的血浆ANP水平（p < 0.05）。通过高效液相色谱法对心钠素样免疫反应物质的分析表明，α - ANP是患有心脏病儿童血液中循环ANP的主要形式。
