Dallas Nephrology Associates, Dallas, TX.
University of Texas Health Science Center at San Antonio, San Antonio, TX.
Am J Kidney Dis. 2017 Aug;70(2):301-304. doi: 10.1053/j.ajkd.2017.01.041. Epub 2017 Mar 23.
Cryoglobulinemia is a manifestation of hepatitis C virus (HCV) infection. Treatment of HCV is the mainstay of therapy for mixed cryoglobulinemia syndrome, and newer HCV therapies with direct-acting antiviral agents have achieved great success in treating HCV infection compared with pegylated interferon alfa and ribavirin. Recurrence of mixed cryoglobulinemia syndrome following successful treatment with direct-acting antiviral agents is uncommon, and when it occurs, it is most often due to relapse of HCV viremia. We report a case of recurrent mixed cryoglobulinemia syndrome following HCV treatment with a new direct-acting antiviral agent (sofosbuvir) and ribavirin, in which HCV RNA was undetectable in serum, but detectable in the cryoprecipitate.
冷球蛋白血症是丙型肝炎病毒（HCV）感染的一种表现。治疗 HCV 是混合性冷球蛋白血症综合征治疗的主要方法，与聚乙二醇干扰素α和利巴韦林相比，新型直接作用抗病毒药物在治疗 HCV 感染方面取得了巨大成功。用直接作用抗病毒药物成功治疗后混合性冷球蛋白血症综合征的复发并不常见，当发生时，通常是由于 HCV 病毒血症的复发。我们报告了一例用新型直接作用抗病毒药物（索非布韦）和利巴韦林治疗 HCV 后混合性冷球蛋白血症综合征复发的病例，血清中 HCV RNA 检测不到，但在冷沉淀物中可检测到。
