Herranz Fernando, Salinas Beatriz, Groult Hugo, Pellico Juan, Lechuga-Vieco Ana V, Bhavesh Riju, Ruiz-Cabello J
Advanced Imaging Unit, Department of Epidemiology, Atherothrombosis and Imaging, Spanish National Centre for Cardiovascular Research (CNIC), Melchor Fernández Almagro, 3, 28029 Madrid, Spain.
CIBER of Pulmonary Diseases, Biomedical Research Network, Carlos III Health Institute, 28029 Madrid, Spain.
Nanomaterials (Basel). 2014 Jun 5;4(2):408-438. doi: 10.3390/nano4020408.
The production of magnetic nanoparticles of utmost quality for biomedical imaging requires several steps, from the synthesis of highly crystalline magnetic cores to the attachment of the different molecules on the surface. This last step probably plays the key role in the production of clinically useful nanomaterials. The attachment of the different biomolecules should be performed in a defined and controlled fashion, avoiding the random adsorption of the components that could lead to undesirable byproducts and ill-characterized surface composition. In this work, we review the process of creating new magnetic nanomaterials for imaging, particularly for the detection of atherosclerotic plaque, . Our focus will be in the different biofunctionalization techniques that we and several other groups have recently developed. Magnetic nanomaterial functionalization should be performed by chemoselective techniques. This approach will facilitate the application of these nanomaterials in the clinic, not as an exception, but as any other pharmacological compound.
生产用于生物医学成像的高质量磁性纳米颗粒需要几个步骤，从合成高度结晶的磁芯到在表面附着不同的分子。最后这一步可能在生产临床可用的纳米材料中起关键作用。不同生物分子的附着应以明确且可控的方式进行，避免成分的随机吸附，因为这可能导致不良副产物和表面组成特征不明。在这项工作中，我们回顾了用于成像，特别是用于检测动脉粥样硬化斑块的新型磁性纳米材料的制备过程。我们将重点关注我们和其他几个小组最近开发的不同生物功能化技术。磁性纳米材料的功能化应通过化学选择性技术来进行。这种方法将促进这些纳米材料在临床上的应用，不是作为特例，而是像任何其他药理化合物一样。
