Mofidi Mani, Negaresh Narges, Farsi Davood, Rezai Mahdi, Mahshidfar Babak, Abbasi Saeed, Hafezimoghadam Peyman
Emergency Medicine Management Research Center, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Turk J Emerg Med. 2016 Nov 24;17(1):29-31. doi: 10.1016/j.tjem.2016.11.001. eCollection 2017 Mar.
Meningitis is an important disease among the patients being visited in Emergency Departments (EDs). There are many signs to diagnose it with different sensitivity and specificity reported in previously done studies. Current study tries to evaluate diagnostic accuracy of "Jolt accentuation" in the diagnosis (Dx.) of meningitis in patients with fever and headache.
48 adult patients, who were referred to two teaching EDs for fever and headache and were diagnosed as suspected meningitis, were included in this prospective observational study. Demographic characteristics of patients were recorded in data sheets, as well as the results of exams including nuchal rigidity, Kernig and Brudzinski signs, and Jolt accentuation. Then, lumbar puncture (LP) was done and cerebrospinal fluid (CSF) was analyzed for each patient; pleocytosis (more than five white blood cells in high power field) were considered as meningitis. Sensitivity, specificity, positive and negative predictive values (PPV and NPV), and positive and negative likelihood ratios (LR and LR) of the above mentioned signs were compared to each other.
Meningitis was proved in 33 patients (68.8% of them), according to CSF analysis. Jolt accentuation had sensitivity, specificity, PPV, NPV, LR, and LR of 69.6%, 33.3%, 69.6%, 33.3%, 1.02, and 0.91, respectively. Jolt accentuation had the highest sensitivity rate all of the signs mentioned above; although, it was not significant.
Jolt accentuation alone cannot rule in or out the Dx. of meningitis in patients with fever and headache; LP is still recommended for these patients.
脑膜炎是急诊科就诊患者中的一种重要疾病。先前的研究报道了许多用于诊断脑膜炎的体征,其敏感性和特异性各不相同。本研究旨在评估“轻推试验”在诊断发热伴头痛患者脑膜炎中的诊断准确性。
本前瞻性观察性研究纳入了48例因发热和头痛被转诊至两家教学医院急诊科且被诊断为疑似脑膜炎的成年患者。患者的人口统计学特征以及包括颈项强直、克尼格征和布鲁津斯基征、轻推试验在内的检查结果均记录在数据表中。然后,对每位患者进行腰椎穿刺(LP)并分析脑脊液(CSF);每高倍视野白细胞超过5个的脑脊液细胞增多症被视为脑膜炎。比较上述体征的敏感性、特异性、阳性和阴性预测值(PPV和NPV)以及阳性和阴性似然比(LR+和LR−)。
根据脑脊液分析,33例患者(68.8%)被证实患有脑膜炎。轻推试验的敏感性、特异性、PPV、NPV、LR+和LR−分别为69.6%、33.3%、69.6%、33.3%、1.02和0.91。轻推试验在上述所有体征中敏感性最高;尽管差异无统计学意义。
仅靠轻推试验不能确诊或排除发热伴头痛患者的脑膜炎诊断;对于这些患者,仍建议进行腰椎穿刺。