Walsh T J
Pediatric Branch, National Cancer Institute, Bethesda, Maryland.
Methods Find Exp Clin Pharmacol. 1987 Nov;9(11):769-78.
Systemic fungal infections are life-threatening diseases that are occurring with increasing frequency, especially in immunocompromised patients. Advances in the treatment of systemic fungal infections have been achieved through better understanding of two classic antifungal drugs, amphotericin B and flucytosine, and through the recent development of several antifungal azole derivatives. The purpose of this paper is to review the recent advances in pharmacology, toxicology, formulation and clinical trials of antifungal agents for the treatment of systemic mycoses.
全身性真菌感染是一种威胁生命的疾病，其发生频率日益增加，尤其是在免疫功能低下的患者中。通过对两种经典抗真菌药物两性霉素B和氟胞嘧啶的更深入了解，以及通过几种抗真菌唑类衍生物的近期研发，全身性真菌感染的治疗取得了进展。本文的目的是综述用于治疗全身性真菌病的抗真菌药物在药理学、毒理学、制剂和临床试验方面的最新进展。
