Azzarelli B, Felten S, Muller J, Miyamoto R, Purvin V
Division of Neuropathology, Indiana University School of Medicine, Indianapolis 46223.
Laryngoscope. 1988 May;98(5):573-8. doi: 10.1288/00005537-198805000-00020.
Glomus jugulare tumors have the ability to synthesize, store, and secrete biogenic amines. Although the majority of these tumors remain endocrinologically silent, on rare occasions they present either as a pheochromocytoma or with a carcinoid syndrome. We report a 20-year-old male with two intracranial tumors: an intrasellar neoplasm and a glomus jugulare tumor. Catecholamine catabolites in the urine were not increased, and blood pressure was always normal. The pituitary tumor was an adenoma, immunostaining positive for prolactin. The second patient, a 29-year-old hypertensive male, with a glomus jugulare tumor, had increased vanillylmandelic-acid excretion. In both cases, the paraganglioma tumor cells contained numerous dense-core vesicles (125 to 380 nm in diameter) in electron microscopy, and showed intense fluorescence by the sucrose-potassium phosphate-glyoxylic acid method. Using high-performance liquid chromatography and microspectrofluorometry we were able to establish the presence of large amounts of dopamine in the cytoplasm of the tumor cells.
颈静脉球瘤具有合成、储存和分泌生物胺的能力。虽然这些肿瘤大多数在内分泌方面无明显表现，但在极少数情况下，它们会表现为嗜铬细胞瘤或类癌综合征。我们报告一例20岁男性，患有两个颅内肿瘤：一个鞍内肿瘤和一个颈静脉球瘤。尿中儿茶酚胺代谢产物未增加，血压始终正常。垂体肿瘤为腺瘤，催乳素免疫染色呈阳性。第二例患者是一名29岁的高血压男性，患有颈静脉球瘤，香草扁桃酸排泄增加。在这两个病例中，副神经节瘤肿瘤细胞在电子显微镜下含有大量直径为125至380纳米的致密核心囊泡，并且通过蔗糖 - 磷酸钾 - 乙醛酸法显示出强烈的荧光。使用高效液相色谱法和显微分光荧光测定法，我们能够确定肿瘤细胞的细胞质中存在大量多巴胺。
