Morse B, Rotherg P G, South V J, Spandorfer J M, Astrin S M
Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111.
Nature. 1988 May 5;333(6168):87-90. doi: 10.1038/333087a0.
The proto-oncogene c-myc is the cellular homologue of the transforming sequence carried by the avian myelocytomastosis virus MC29. A growing body of evidence implicates structural and functional alterations in and around proto-oncogenes such as c-myc in tumorogenesis. Here we report that comparison of the structure of myc from a ductal adenocarcinoma of the breast and from normal breast tissue of the same patient (Sc) revealed a tumour-specific rearrangement of one myc locus and amplification of the other myc locus. (For myc reviews see refs 1-4; for myc involvement in breast neoplasia see refs 5-7.) Within the second intron of the rearranged locus was a non-myc sequence with nearly complete homology to a long interspersed repetitive element (a LINE-1 sequence or L1). In this case, the L1 sequence has functioned as a mobile genetic element to produce a somatic mutation.
原癌基因c-myc是禽骨髓细胞瘤病毒MC29携带的转化序列的细胞同源物。越来越多的证据表明，原癌基因（如c-myc）及其周围的结构和功能改变与肿瘤发生有关。本文报道，对一名患者乳腺导管腺癌和正常乳腺组织（Sc）中myc结构的比较显示，一个myc基因座发生肿瘤特异性重排，另一个myc基因座扩增。（关于myc的综述见参考文献1-4；关于myc参与乳腺肿瘤形成见参考文献5-7。）在重排基因座的第二个内含子中有一个与长散在重复元件（LINE-1序列或L1）几乎完全同源的非myc序列。在这种情况下，L1序列作为一个可移动的遗传元件发挥作用，产生了一个体细胞突变。
