Samuelson U E, Wiklund N P, Gustafsson L E
Department of Physiology, Karolinska Institute, Stockholm, Sweden.
Neurosci Lett. 1988 Mar 21;86(1):51-5. doi: 10.1016/0304-3940(88)90181-4.
In the present investigation we have examined the possibility that endogenous purines may act as neuromodulatory agents in the human fallopian tube, using the selective adenosine receptor antagonist 8-p-sulfophenyltheophylline (PSOT). PSOT applied to untreated preparations enhanced the contractile responses to transmural nerve stimulation in the human fallopian tube, both in the secretory and proliferative hormonal phases. Furthermore, PSOT enhanced nerve-induced [3H]noradrenaline release during both hormonal phases. This can be taken as indirect evidence that endogenous purines inhibited the adrenergic neuroeffector transmission under the experimental conditions. The inhibitory effect presumably was exerted at both pre- and postjunctional adenosine receptors.
在本研究中，我们使用选择性腺苷受体拮抗剂8-对磺基苯甲基黄嘌呤（PSOT），研究了内源性嘌呤可能作为人输卵管神经调节因子的可能性。将PSOT应用于未经处理的标本时，在人输卵管的分泌期和增殖期激素阶段，均增强了对跨壁神经刺激的收缩反应。此外，在两个激素阶段，PSOT均增强了神经诱导的[3H]去甲肾上腺素释放。这可以作为间接证据，表明在实验条件下内源性嘌呤抑制了肾上腺素能神经效应传递。推测这种抑制作用是在突触前和突触后腺苷受体上发挥的。
