a Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy , State University of Maringa , Maringa , Brazil.
Pharm Dev Technol. 2018 Jan;23(1):1-12. doi: 10.1080/10837450.2017.1312441. Epub 2017 Apr 12.
Bladder cancer (BC) is the most common tumor type of genitourinary tract, which affects more men than women. The conventional treatment is through chemotherapy or immunotherapy, but the radiotherapy and surgery may be necessary in cases of invasive cancer. The search for less invasive, safe and effective therapies has attracted researchers to the development of new drug delivery systems to carry drugs to be administered by catheter into the bladder. The research on intravesical systems for the BC treatment continues at a rapid pace and a variety of micro or nanostructured systems have been used. Micro/nanoparticles, liposomes, micelles, carbon nanotubes, hydrogels and nanogels can contribute to reduce the number of intravesical administrations due to the extended drug release as well as to reduce the adverse effects and to increase the patient adherence to the treatment. Thus, this article reviews relevant studies regarding these systems, which have shown promising perspectives for the treatment of BC. It is hoped that in a near future they can prove to be safe and efficient to benefit patients with BC.
膀胱癌（BC）是最常见的泌尿生殖道肿瘤类型，男性发病率高于女性。传统的治疗方法是化疗或免疫疗法，但对于侵袭性癌症，放疗和手术可能是必要的。为了寻找更微创、安全和有效的治疗方法，研究人员致力于开发新的药物输送系统，通过导管将药物输送到膀胱。BC 治疗的膀胱内系统研究进展迅速，已经使用了多种微纳米结构系统。微/纳米粒子、脂质体、胶束、碳纳米管、水凝胶和纳米凝胶可以通过延长药物释放来减少膀胱内给药次数，从而减少不良反应，并提高患者对治疗的依从性。因此，本文综述了这些系统的相关研究，这些研究为 BC 的治疗提供了有前景的方法。希望在不久的将来，它们能够被证明是安全有效的，从而使 BC 患者受益。
