Department of Cognitive Neuroscience,Radboud University Medical Center,6500 HB Nijmegen,The
Behav Brain Sci. 2016 Jan;39:e222. doi: 10.1017/S0140525X15001934.
Mather and colleagues postulate that norepinephrine promotes selective processing of emotionally salient information through local "hotspots" where norepinephrine release interacts with glutamatergic activity. However, findings in rodents and humans indicate that norepinephrine is ineffective in modulating mnemonic processes in the absence of a functional amygdala. We therefore argue that emphasis should shift toward modulatory effects of amygdala-driven changes at the network level.
马瑟和同事假设去甲肾上腺素通过局部“热点”促进情绪相关信息的选择性处理，在此处去甲肾上腺素的释放与谷氨酸能活性相互作用。然而，在啮齿动物和人类中的发现表明，在杏仁核功能正常的情况下，去甲肾上腺素在调节记忆过程方面是无效的。因此，我们认为应该将重点转移到杏仁核驱动的网络水平变化的调节作用上。
