Carstens M E, Engelbrecht A H, Russell V A, van Zyl A M, Taljaard J J
Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, Republic of South Africa.
Psychiatry Res. 1988 Jan;23(1):77-88. doi: 10.1016/0165-1781(88)90036-4.
3H-p-Aminoclonidine binding to platelets of children and adolescents with major depressive disorder was compared to that of a healthy control population. Significantly higher alpha 2-adrenoceptor Kd and Bmax values were observed in the patient population. 3H-Dihydroalprenolol binding to lymphocyte membranes of the same patient population showed significantly higher beta-adrenoceptor Bmax values than controls. Control females had significantly higher beta-adrenoceptor Kd values than control males, and the female patients had significantly lower beta-adrenoceptor Kd values than control females. 3H-Imipramine binding to platelets of these patients showed significantly higher imipramine Kd values in patients with a suicide attempt, whereas the imipramine Bmax values were significantly increased in patients with major depressive disorder with or without a suicide attempt. We propose that increased platelet alpha 2-adrenoceptor Kd and Bmax values, together with increased platelet imipramine Kd values, may serve as possible biological markers for children and adolescents with major depressive disorder and a tendency toward suicide. Elevated platelet imipramine and lymphocyte beta-adrenoceptor Bmax values may be biological markers for juvenile depression, and decreased beta-adrenoceptor Kd values may be a biological marker for depression in young females.
将患有重度抑郁症的儿童和青少年血小板上的3H-对氨基可乐定结合情况与健康对照人群进行比较。在患者群体中观察到α2-肾上腺素能受体的解离常数（Kd）和最大结合容量（Bmax）值显著更高。对同一患者群体的淋巴细胞膜进行3H-二氢心得静结合实验，结果显示其β-肾上腺素能受体的Bmax值显著高于对照组。对照女性的β-肾上腺素能受体Kd值显著高于对照男性，而女性患者的β-肾上腺素能受体Kd值显著低于对照女性。这些患者血小板上的3H-丙咪嗪结合实验表明，有自杀企图的患者丙咪嗪Kd值显著更高，而无论有无自杀企图的重度抑郁症患者丙咪嗪Bmax值均显著升高。我们认为，血小板α2-肾上腺素能受体Kd和Bmax值升高，以及血小板丙咪嗪Kd值升高，可能是患有重度抑郁症且有自杀倾向的儿童和青少年的潜在生物学标志物。血小板丙咪嗪和淋巴细胞β-肾上腺素能受体Bmax值升高可能是青少年抑郁症的生物学标志物，而β-肾上腺素能受体Kd值降低可能是年轻女性抑郁症的生物学标志物。
