Carstens M E, Engelbrecht A H, Russell V A, Aalbers C, Gagiano C A, Chalton D O, Taljaard J J
Psychiatry Res. 1986 Aug;18(4):321-31. doi: 10.1016/0165-1781(86)90017-x.
3H-p-Aminoclonidine binding to platelets of patients with primary, unipolar major depressive disorder was compared to that of a normal healthy control population. The variances of platelet alpha 2-adrenoceptor Kd and Bmax values in patients were significantly greater than in the control group. No significant difference could be demonstrated between the Kd values of the two different groups, but the Bmax value of the depressed group was significantly lower than that of controls. We propose that an abnormal platelet alpha 2-adrenoceptor density may be used as a biological marker for major depressive disorder.
将原发性单相重度抑郁症患者血小板上的3H-p-氨基可乐定结合情况与正常健康对照人群进行了比较。患者血小板α2-肾上腺素能受体Kd和Bmax值的方差显著大于对照组。两组的Kd值之间未显示出显著差异，但抑郁症组的Bmax值显著低于对照组。我们提出，异常的血小板α2-肾上腺素能受体密度可作为重度抑郁症的生物学标志物。
