Department of Pathology, University of Miami, Miami, Florida 33136.
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):a029504. doi: 10.1101/cshperspect.a029504.
Simian immunodeficiency virus (SIV) challenge of rhesus macaques provides an invaluable tool to evaluate the clinical prospects of HIV-1 vaccine concepts. However, as with any animal model of human disease, it is crucial to understand the advantages and limitations of this system to maximize the translational value of SIV vaccine studies. Here, we discuss the importance of assessing the efficacy of vaccine prototypes using stringent SIV challenge regimens that mimic HIV-1 transmission and pathogenesis. We also review some of the cautionary tales of HIV-1 vaccine research because they provide general lessons for the preclinical assessment of vaccine candidates.
恒河猴感染猴免疫缺陷病毒（SIV）模型为评估 HIV-1 疫苗概念的临床前景提供了非常有价值的工具。然而，就像任何人类疾病的动物模型一样，了解该系统的优势和局限性对于最大限度地提高 SIV 疫苗研究的转化价值至关重要。在这里，我们讨论了使用模拟 HIV-1 传播和发病机制的严格 SIV 挑战方案来评估疫苗原型功效的重要性。我们还回顾了一些 HIV-1 疫苗研究的警示故事，因为它们为疫苗候选物的临床前评估提供了一般性的经验教训。
