具有共缩合钆螯合物的介孔二氧化硅纳米颗粒用于多模态成像。
Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging.
作者信息
Taylor-Pashow Kathryn M L, Rocca Joseph Della, Lin Wenbin
机构信息
Savannah River National Laboratory, Savannah River Site, Bldg. 773-A, Aiken, SC 29808, USA.
Department of Chemistry, CB #3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Nanomaterials (Basel). 2011 Dec 27;2(1):1-14. doi: 10.3390/nano2010001.
Several mesoporous silica nanoparticle (MSN) contrast agents have been synthesized using a co-condensation method to incorporate two different Gd complexes at very high loadings (15.5-28.8 wt %). These MSN contrast agents, with an MCM-41 type pore structure, were characterized using a variety of methods including SEM and TEM, nitrogen adsorption measurements, thermogravimetric analysis (TGA), direct current plasma (DCP) spectroscopy, and powder X-ray diffraction (PXRD). The magnetic resonance (MR) relaxivities of these contrast agents were determined using a 3 T MR scanner. The r₁ relaxivities of these nanoparticles range from 4.1 to 8.4 mMs on a per Gd basis. Additionally, the MSN particles were functionalized with an organic fluorophore and cancer cell targeting peptide to allow for demonstration of both the optical and MR contrast enhancing capabilities in vitro.
已经使用共缩聚方法合成了几种介孔二氧化硅纳米颗粒（MSN）造影剂，以非常高的负载量（15.5-28.8 wt%）掺入两种不同的钆配合物。这些具有MCM-41型孔结构的MSN造影剂使用多种方法进行了表征，包括扫描电子显微镜（SEM）和透射电子显微镜（TEM）、氮吸附测量、热重分析（TGA）、直流等离子体（DCP）光谱和粉末X射线衍射（PXRD）。使用3 T磁共振扫描仪测定了这些造影剂的磁共振（MR）弛豫率。这些纳米颗粒的r₁弛豫率以每钆计在4.1至8.4 mM/s范围内。此外，MSN颗粒用有机荧光团和癌细胞靶向肽进行了功能化，以便在体外展示光学和MR造影增强能力。
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