Rontoyanni Victoria G, Nunez Lopez Omar, Fankhauser Grant T, Cheema Zulfiqar F, Rasmussen Blake B, Porter Craig
Metabolism Unit, Shriners Hospitals for ChildrenGalveston, TX, USA; Department of Surgery, University of Texas Medical BranchGalveston, TX, USA.
Department of Surgery, University of Texas Medical Branch Galveston, TX, USA.
Front Physiol. 2017 Mar 13;8:141. doi: 10.3389/fphys.2017.00141. eCollection 2017.
Peripheral artery disease (PAD) is a serious but relatively underdiagnosed and undertreated clinical condition associated with a marked reduction in functional capacity and a heightened risk of morbidity and mortality. The pathophysiology of lower extremity PAD is complex, and extends beyond the atherosclerotic arterial occlusion and subsequent mismatch between oxygen demand and delivery to skeletal muscle mitochondria. In this review, we evaluate and summarize the available evidence implicating mitochondria in the metabolic myopathy that accompanies PAD. Following a short discussion of the available and methodologies to quantitate indices of muscle mitochondrial function, we review the current evidence implicating skeletal muscle mitochondrial dysfunction in the pathophysiology of PAD myopathy, while attempting to highlight questions that remain unanswered. Given the rising prevalence of PAD, the detriment in quality of life for patients, and the associated significant healthcare resource utilization, new alternate therapies that ameliorate lower limb symptoms and the functional impairment associated with PAD are needed. A clear understanding of the role of mitochondria in the pathophysiology of PAD may contribute to the development of novel therapeutic interventions.
外周动脉疾病（PAD）是一种严重但相对诊断不足和治疗不足的临床病症，与功能能力显著下降以及发病和死亡风险增加有关。下肢PAD的病理生理学很复杂，不仅限于动脉粥样硬化性动脉闭塞以及随后骨骼肌线粒体氧需求与供应之间的不匹配。在本综述中，我们评估并总结了现有证据，这些证据表明线粒体与PAD伴随的代谢性肌病有关。在简短讨论了用于定量肌肉线粒体功能指标的现有方法后，我们回顾了目前有关骨骼肌线粒体功能障碍参与PAD肌病病理生理学的证据，同时试图突出尚未解答的问题。鉴于PAD患病率不断上升、患者生活质量受损以及相关的大量医疗资源利用，需要新的替代疗法来改善下肢症状以及与PAD相关的功能损害。清楚了解线粒体在PAD病理生理学中的作用可能有助于开发新的治疗干预措施。
