冠状动脉疾病患者肱动脉血流介导的扩张、颈动脉内膜中层厚度与冠状动脉血流储备之间的关系
Relationship Between Brachial Artery Flow-Mediated Dilation, Carotid Artery Intima-Media Thickness and Coronary Flow Reserve in Patients With Coronary Artery Disease.
作者信息
Oz Fahrettin, Elitok Ali, Bilge Ahmet Kaya, Mercanoglu Fehmi, Oflaz Huseyin
机构信息
Department of Cardiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
出版信息
Cardiol Res. 2012 Oct;3(5):214-221. doi: 10.4021/cr219w. Epub 2012 Sep 20.
BACKGROUND
The aim of this study was to assess the relationship between brachial artery flow mediated dilation (FMD), carotid artery intima-media thickness (IMT) and coronary flow reserve (CFR) in patients with coronary artery disease (CAD).
METHODS
Fifty patients with coronary artery disease, except left anterior descending artery (LAD), who showed no cardiac symptoms and 45 control subjects underwent assessment of brachial artery FMD, carotid artery intima-media thickness by high-resolution ultrasound. In addition, transthoracic second harmonic Doppler echocardiography was used to measure CFR.
RESULTS
All of the parameters were found to be correlated with each other. CFR correlated with brachial artery FMD (r = 0.232, P < 0.05) and with carotid IMT (r = -0.403, P < 0.001). Carotid IMT correlated with brachial artery FMD (r = -0.211, P < 0.05).
CONCLUSION
Transthoracic CFR correlated with well-established noninvasive predictors of atherosclerosis and we suggest that it can be used as a surrogate for coronary atherosclerosis.
背景
本研究旨在评估冠心病（CAD）患者肱动脉血流介导的舒张功能（FMD）、颈动脉内膜中层厚度（IMT）与冠状动脉血流储备（CFR）之间的关系。
方法
50例除左前降支（LAD）外无心脏症状的冠心病患者和45例对照者接受了肱动脉FMD、高分辨率超声测量颈动脉内膜中层厚度的评估。此外，经胸二次谐波多普勒超声心动图用于测量CFR。
结果
所有参数均被发现相互关联。CFR与肱动脉FMD相关（r = 0.232，P < 0.05），与颈动脉IMT相关（r = -0.403，P < 0.001）。颈动脉IMT与肱动脉FMD相关（r = -0.211，P < 0.05）。
结论
经胸CFR与已确立的动脉粥样硬化非侵入性预测指标相关，我们建议它可作为冠状动脉粥样硬化的替代指标。
Zotero 插件