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人类首例肠炎病例报告。

First reported case of enteritis in a human.

作者信息

Lévesque Simon, Lemay Frédéric, Bekal Sadjia, Frost Eric H, Michaud Sophie

机构信息

Laboratoire de santé publique du Québec/Institut national de santé publique du Québec, Sainte-Anne-de-Bellevue, Québec , Canada.

Faculté de Médecine et des sciences de la santé de l'Université de Sherbrooke, Sherbrooke, Québec, Canada; Centre de recherche du Centre hospitalier universitaire de Sherbrooke(CHUS), Sherbrooke, Québec, Canada.

出版信息

JMM Case Rep. 2016 Jun 28;3(3):e005045. doi: 10.1099/jmmcr.0.005045. eCollection 2016 Jun.

Abstract

INTRODUCTION

Campylobacters are the most frequently identified bacteria causing diarrhoea in humans worldwide. was isolated for the first time in 2000 from faecal samples of two asymptomatic abattoir workers in Switzerland during a routine hygiene screen, but has never been associated with human disease.

CASE PRESENTATION

At hospital admission, the patient reported diarrhoea, lower abdominal cramps, nausea, one episode of bilious vomiting and low-grade fever of 38 °C. The patient was having 10 or more diarrheic stools per day as well as during the night, and had noticed blood mixed with the stools on several occasions. Stool cultures were negative for species of and , O157:H7 and , but were positive for . Identification was made by classical biochemical testing, as well as 16S rRNA gene and sequencing. The patient slowly improved without antibiotic treatment and was discharged nine days after admission with complete resolution of symptoms.

CONCLUSION

On the whole it seems very likely that was the causative agent. Clinical microbiologists should be aware of this micro-organism which can be identified by phenotypic and molecular methods. The real burden of infection in humans might be underestimated and should be further investigated as a potential cause of human diarrhoea disease.

摘要

引言

弯曲杆菌是全球范围内导致人类腹泻最常见的细菌。2000年在瑞士对两名无症状屠宰场工人进行常规卫生筛查时,首次从其粪便样本中分离出该菌,但它从未与人类疾病相关联。

病例报告

入院时,患者自述有腹泻、下腹部绞痛、恶心、一次胆汁性呕吐以及38°C的低热。患者每天腹泻10次或更多,夜间也如此,且多次注意到粪便中混有血液。粪便培养对沙门氏菌属、志贺氏菌属、O157:H7大肠杆菌和霍乱弧菌检测均为阴性,但对[该菌名称]检测呈阳性。通过经典生化检测以及16S rRNA基因和[相关基因名称]测序进行鉴定。患者未经抗生素治疗病情逐渐好转,入院九天后出院,症状完全消失。

结论

总体而言,[该菌名称]很可能是病原体。临床微生物学家应了解这种可通过表型和分子方法鉴定的微生物。[该菌名称]感染在人类中的实际负担可能被低估,应作为人类腹泻病的潜在病因进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fad4/5330232/630a0ea028f6/jmmcr-03-5045-f001.jpg

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