Mulroy Eoin, Walker Elizabeth
Department of Neurology, Auckland City Hospital, 2 Park Road, Auckland, New Zealand.
Epilepsy Behav Case Rep. 2017 Jan 18;7:40-41. doi: 10.1016/j.ebcr.2016.12.004. eCollection 2017.
Immune-mediated drug reactions are a potentially life-threatening complication of antiseizure medications. Drug hypersensitivity syndrome (DHS) is the best recognised of these, presenting with fever, eosinophilia, rash and internal organ involvement. Isolated lymphadenopathy is a less recognized immune-mediated reaction to antiseizure drugs such as lamotrigine. We describe the case of a 24-year-old woman who developed lamotrigine-related bilateral cervical lymphadenopathy (pseudolymphoma) fifteen months following therapy initiation. This is the second such case reported in the medical literature.
免疫介导的药物反应是抗癫痫药物潜在的危及生命的并发症。药物超敏反应综合征（DHS）是其中最广为人知的，表现为发热、嗜酸性粒细胞增多、皮疹和内脏器官受累。孤立性淋巴结病是对拉莫三嗪等抗癫痫药物较少被认识的免疫介导反应。我们描述了一名24岁女性的病例，她在开始治疗15个月后出现了与拉莫三嗪相关的双侧颈部淋巴结病（假性淋巴瘤）。这是医学文献中报道的第二例此类病例。
