中国汉族人群2型糖尿病患者中STK11基因多态性与冠状动脉疾病的关联
Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China.
作者信息
Ma Xiaowei, Bai Ge, Lu Difei, Huang Linjuan, Zhang Jianwei, Deng Ruifen, Ding Shan, Gu Nan, Guo Xiaohui
机构信息
Department of Endocrinology, Peking University First Hospital, Beijing, China.
出版信息
J Diabetes Res. 2017;2017:6297087. doi: 10.1155/2017/6297087. Epub 2017 Feb 28.
. Recent studies indicated that the Serine threonine kinase 11 (STK11), which is a key regulator of the AMP-activated protein kinase (AMPK), plays a crucial role in cardiovascular system. This study aimed to investigate whether genetic variations in the STK11 gene affect the risk of coronary artery disease (CAD) in Chinese type 2 diabetics. . 5 haplotype-tagging single nucleotide polymorphisms (SNPs) were selected, and 288 CAD-positive cases and 159 CAD-negative controls with type 2 diabetes were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. . The carriers of minor allele A at rs12977689 had a higher risk of CAD compared to the homozygotes of CC (OR = 1.572, 95% CI = 1.039-2.376, = 0.035), and the difference was still significant after adjustment for the other known CAD risk factors (OR' = 1.184, 95% CI' = 1.036-1.353, ' = 0.013). . Genetic variability at STK11 locus is associated with CAD risk in type 2 diabetes in the Chinese population.
近期研究表明，丝氨酸苏氨酸激酶11（STK11）作为AMP激活的蛋白激酶（AMPK）的关键调节因子，在心血管系统中发挥着至关重要的作用。本研究旨在探讨STK11基因的遗传变异是否会影响中国2型糖尿病患者患冠状动脉疾病（CAD）的风险。选择了5个单倍型标签单核苷酸多态性（SNP），并通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析对288例CAD阳性的2型糖尿病患者和159例CAD阴性对照进行基因分型。与CC纯合子相比，rs12977689位点携带次要等位基因A的个体患CAD的风险更高（OR = 1.572，95%CI = 1.039 - 2.376，P = 0.035），在对其他已知CAD风险因素进行校正后，差异仍然显著（OR' = 1.184，95%CI' = 1.036 - 1.353，P' = 0.013）。STK11基因座的遗传变异性与中国人群2型糖尿病患者的CAD风险相关。
Zotero 插件