Endocrinology Department, Peking University First Hospital, No. 8, Xishiku Street, Beijing 100034, China.
J Diabetes Res. 2017;2017:4501794. doi: 10.1155/2017/4501794. Epub 2017 Aug 3.
We investigated the association between ubiquitin-conjugating enzyme E2Z (UBE2Z) gene SNP rs46522 and the risk of CAD in a Chinese Han population with type 2 diabetes and explored a possible interactive effect with environmental risk factors of CAD.
665 patients with T2D were enrolled; 390 were CAD patients and 275 were non-CAD patients. Genotype analysis of rs46522 (T>C) was performed using PCR-RFLP.
The SNP rs47522 was associated with the risk of CAD supposing recessive inheritance model (TT versus CC+CT, OR' = 1.277, 95%CI' 1.039-1.570, ' = 0.020) and codominant model (TT versus CT, OR' = 1.673, 95%CI' 1.088-2.570, ' = 0.019) after adjustment for confounders of CAD. A synergistic effect of rs46522 and BMI was discovered ( = 0.012, = 0.028). In subgroup analysis, minor allele T was significantly associated with CAD in overweight and obesity subgroup ( = 0.034), and the association was also proved in recessive model (OR = 1.537, 95%CI 1.075-2.196, = 0.018). Smokers with genotype TT had threefold risk of CAD in comparison to nonsmokers with genotype TC or CC ( < 0.001).
The SNP rs46522 in UBE2Z gene is associated with the risk of CAD in the individuals of Chinese Han descent with type 2 diabetes and is of synergistic effect with BMI.
我们在中国汉族 2 型糖尿病患者中研究了泛素结合酶 E2Z (UBE2Z) 基因 SNP rs46522 与 CAD 风险的关联，并探讨了其与 CAD 环境危险因素的可能交互作用。
纳入 665 例 2 型糖尿病患者；其中 390 例为 CAD 患者，275 例为非 CAD 患者。采用 PCR-RFLP 法对 rs46522 (T>C) 进行基因型分析。
在调整 CAD 的混杂因素后，假定隐性遗传模型（TT 与 CC+CT，OR' = 1.277，95%CI' 1.039-1.570，' = 0.020）和共显性模型（TT 与 CT，OR' = 1.673，95%CI' 1.088-2.570，' = 0.019），SNP rs47522 与 CAD 风险相关。发现 rs46522 与 BMI 存在协同作用（ = 0.012， = 0.028）。在亚组分析中，在超重和肥胖亚组中，等位基因 T 与 CAD 显著相关（ = 0.034），并且在隐性模型中也得到了证明（OR = 1.537，95%CI 1.075-2.196， = 0.018）。与基因型 TC 或 CC 的非吸烟者相比，基因型 TT 的吸烟者患 CAD 的风险增加了三倍（ < 0.001）。
UBE2Z 基因中的 SNP rs46522 与中国汉族 2 型糖尿病患者的 CAD 风险相关，与 BMI 存在协同作用。
