Wong Brett J, Hollowed Casey G
Department of Kinesiology & Health, Georgia State University, Atlanta, GA, USA.
Temperature (Austin). 2016 Jun 21;4(1):41-59. doi: 10.1080/23328940.2016.1200203. eCollection 2017.
In humans, an increase in internal core temperature elicits large increases in skin blood flow and sweating. The increase in skin blood flow serves to transfer heat via convection from the body core to the skin surface while sweating results in evaporative cooling of the skin. Cutaneous vasodilation and sudomotor activity are controlled by a sympathetic cholinergic active vasodilator system that is hypothesized to operate through a co-transmission mechanism. To date, mechanisms of cutaneous active vasodilation remain equivocal despite many years of research by several productive laboratory groups. The purpose of this review is to highlight recent advancements in the field of cutaneous active vasodilation framed in the context of some of the historical findings that laid the groundwork for our current understanding of cutaneous active vasodilation.
在人类中，体内核心温度升高会引起皮肤血流量和出汗量大幅增加。皮肤血流量的增加有助于通过对流将热量从身体核心传递到皮肤表面，而出汗则导致皮肤的蒸发散热。皮肤血管舒张和发汗运动由交感胆碱能活性血管舒张系统控制，该系统被认为是通过共同传递机制发挥作用的。尽管多个活跃的实验室团队经过多年研究，但迄今为止，皮肤活性血管舒张的机制仍不明确。本综述的目的是强调皮肤活性血管舒张领域的最新进展，这些进展是在一些为我们当前对皮肤活性血管舒张的理解奠定基础的历史发现的背景下阐述的。
