Hayashi Takashi, To Masahiro, Saruta Juri, Sato Chikatoshi, Yamamoto Yuko, Kondo Yusuke, Shimizu Tomoko, Kamata Yohei, Tsukinoki Keiichi
a Division of Environmental Pathology, Department of Oral Science , Graduate School of Dentistry, Kanagawa Dental University , Yokosuka , Japan.
b Division of Dental Anatomy, Department of Oral Science , Graduate School of Dentistry, Kanagawa Dental University , Yokosuka , Japan.
Biosci Biotechnol Biochem. 2017 Jul;81(7):1300-1304. doi: 10.1080/09168451.2017.1308241. Epub 2017 Mar 29.
Lactoferrin (LF) is produced by exocrine glands including salivary gland, and has various functions including infection defense. However, the transfer of LF from peripheral organs into the brain remains unclear. To clarify the kinetics of salivary LF (sLF), we investigated the consequences of sialoadenectomy and bovine LF (bLF) sublingual administration in rats. The salivary glands were removed from male Wistar rats, and we measured rat LF levels in the blood and brain at 1 week post-surgery. We also examined the transfer of LF into the organs of the rats after sublingual administration of bLF. Rat LF levels in the blood and brain were significantly reduced by sialoadenectomy. Sublingual bLF administration significantly increased bLF levels in the brain, which then decreased over time. These results indicate that LF is transferred from the sublingual mucosa to the brain, in which favorable effects of sLF on brain will be expected via the sublingual mucosa.
乳铁蛋白（LF）由包括唾液腺在内的外分泌腺产生，具有多种功能，包括抗感染。然而，LF从外周器官向大脑的转运尚不清楚。为了阐明唾液LF（sLF）的动力学，我们研究了大鼠唾液腺切除和牛LF（bLF）舌下给药的后果。从雄性Wistar大鼠身上摘除唾液腺，我们在手术后1周测量了血液和大脑中的大鼠LF水平。我们还研究了bLF舌下给药后LF在大鼠器官中的转运情况。唾液腺切除显著降低了血液和大脑中的大鼠LF水平。舌下给予bLF显著提高了大脑中的bLF水平，随后其水平随时间下降。这些结果表明，LF从舌下黏膜转运至大脑，由此推测sLF可能通过舌下黏膜对大脑产生有益作用。
Zotero 插件