Department of Physiology, Jagiellonian University Medical College, Cracow, Poland.
J Physiol Pharmacol. 2013 Oct;64(5):657-68.
Ghrelin exhibits protective and therapeutic effect in different parts of the gastrointestinal tract. The aim of the present study was to examine the influence of ghrelin administration on the healing of oral ulcers in rats with intact salivary gland and in sialoadenectomized rats. Gingival and lingual ulcers were induced by acetic acid. After induction of ulcers, rats were treated with saline or ghrelin for six days. In rats with intact salivary glands and induction of oral ulcers, administration of ghrelin significantly increased the healing rate of these ulcers. This result was associated with a significant increase in mucosal blood flow and cell proliferation, and a decrease in concentration of pro-inflammatory interleukin-1β in gingival and lingual mucosa. Sialoadenectomy decreased cell proliferation and increased concentration of pro-inflammatory interleukin-1β in oral mucosa, as well as reduced the healing rate of gingival and lingual ulcers. Administration of ghrelin reversed deleterious effect of sialoadenectomy and increased the healing rate of oral ulcers above a value observed in rats with intact salivary glands.
Treatment with ghrelin accelerates healing of oral ulcers in salivary glands-intact rat, as well as in rats with reduced salivary secretion evoked by sialoadenectomy. Mechanisms of beneficial effects of ghrelin administration involve an increase in mucosal blood flow and cell proliferation, as well as a reduction in local inflammation.
本研究旨在探讨给予 ghrelin 对唾液腺完整大鼠和唾液腺切除大鼠口腔溃疡愈合的影响。
通过乙酸诱导建立牙龈和舌溃疡模型。诱导溃疡后，用生理盐水或 ghrelin 处理大鼠 6 天。
在唾液腺完整且诱导口腔溃疡的大鼠中，ghrelin 的给药显著增加了这些溃疡的愈合率。这一结果与黏膜血流和细胞增殖的显著增加以及牙龈和舌黏膜中促炎细胞因子白细胞介素-1β浓度的降低有关。唾液腺切除降低了口腔黏膜的细胞增殖，增加了促炎细胞因子白细胞介素-1β的浓度，并降低了牙龈和舌溃疡的愈合率。给予 ghrelin 逆转了唾液腺切除的有害影响，并使口腔溃疡的愈合率高于唾液腺完整大鼠的愈合率。
ghrelin 的治疗加速了唾液腺完整大鼠以及由于唾液腺切除导致唾液分泌减少的大鼠的口腔溃疡愈合。ghrelin 给药的有益作用机制涉及增加黏膜血流和细胞增殖，以及减少局部炎症。
