Kurashina M, Kozuka S, Nakasima N, Hirabayasi N, Ito M
Department of Medical Technology, College of Medical Technology, Nagoya University, Japan.
Cancer. 1988 Jun 15;61(12):2469-74. doi: 10.1002/1097-0142(19880615)61:12<2469::aid-cncr2820611214>3.0.co;2-y.
To investigate the relationship between intrahepatic bile duct hyperplasia and cholangiocellular carcinoma, 27 patients with cholangiocellular carcinoma (including biliary cystadenocarcinoma) and 303 controls were histologically examined. Livers with cholangiocellular carcinoma were closely associated with hyperplasia (100%), atypical hyperplasia (77.8%), and carcinoma in situ (51.9%). Transition from hyperplasia to atypical hyperplasia, and from atypical hyperplasia to carcinoma, was often observed. In the controls, hyperplasia was frequent in those older than 30 years of age, whereas carcinoma was frequent in patients from 50 to 80 years of age. Of the intrahepatic bile ducts examined, the large duct showed the highest incidence of hyperplasia, atypical hyperplasia, and carcinoma in situ. All 27 cases of cholangiocellular carcinoma originated in, or near, the hilus of the liver. These findings suggest that cholangiocellular carcinoma frequently develops from bile duct hyperplasia.
为研究肝内胆管增生与胆管细胞癌之间的关系，对27例胆管细胞癌（包括胆管囊腺癌）患者和303例对照者进行了组织学检查。胆管细胞癌患者的肝脏与增生（100%）、非典型增生（77.8%）和原位癌（51.9%）密切相关。常观察到从增生到非典型增生，以及从非典型增生到癌的转变。在对照组中，增生在30岁以上者中常见，而癌在50至80岁患者中常见。在所检查的肝内胆管中，大胆管的增生、非典型增生和原位癌发生率最高。27例胆管细胞癌均起源于肝门或其附近。这些发现提示胆管细胞癌常由胆管增生发展而来。
