Mansouri Maria, Zniber Amal, Boualla Lamia, El Badaoui Ghizlane, Benkacem Mariam, Rifai Kaoutar, Chraibi Abdelmjid, Benamar Loubna, Sefiani Abdelaziz, Bayahia Rabia
Human Genome Center, Faculty of Medicine and Pharmacy, University Mohammed V; Department of Medical Genetics, National Institute of Health, Rabat, Morocco.
Department of Nephrology, Dialysis and Kidney Transplantation, Faculty of Medicine and Pharmacy, Ibn Sina Hospital, University Mohammed V, Rabat, Morocco.
Saudi J Kidney Dis Transpl. 2017 Mar-Apr;28(2):261-267. doi: 10.4103/1319-2442.202792.
Diabetic nephropathy (DN) is one of the severe complications of Type-2 diabetes mellitus (T2DM) and a major cause of end-stage renal disease in these patients. Results from published studies on the relationship between angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) gene polymorphism and patients with DN are still conflicting. We compared the clinical characteristics and the genotype frequencies of ACE polymorphism in 130 T2DM Moroccan patients with DN and 85 T2DM Moroccan patients without DN (controls) using specific primers in a polymerase chain reaction. The degenerative complications of diabetes were significantly higher in the group with nephropathy. The distribution of the I/D genotypes was in Hardy-Weinberg equilibrium. The D allele was the most frequent allele in the Moroccan population in both groups studied (P = 0.68), however, there was no significant difference between the genotypes in T2DM patients with or without DN (P = 0.78). The ACE gene I/D polymorphism was not associated with an increased risk of DN in the Moroccan population.
糖尿病肾病（DN）是2型糖尿病（T2DM）的严重并发症之一，也是这些患者终末期肾病的主要原因。已发表的关于血管紧张素转换酶（ACE）插入/缺失（I/D）基因多态性与DN患者关系的研究结果仍存在矛盾。我们使用聚合酶链反应中的特异性引物，比较了130例患有DN的摩洛哥T2DM患者和85例无DN的摩洛哥T2DM患者（对照组）的临床特征和ACE多态性的基因型频率。肾病组糖尿病的退行性并发症明显更高。I/D基因型的分布符合哈迪-温伯格平衡。在所研究的两组摩洛哥人群中，D等位基因是最常见的等位基因（P = 0.68），然而，有或无DN的T2DM患者的基因型之间没有显著差异（P = 0.78）。在摩洛哥人群中，ACE基因I/D多态性与DN风险增加无关。
J Renin Angiotensin Aldosterone Syst. 2015-3
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