Department of Medicine, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.
J Diabetes. 2012 Sep;4(3):257-61. doi: 10.1111/j.1753-0407.2012.00205.x.
Diabetic peripheral neuropathy (DPN) is one of the complications of type 2 diabetes mellitus (T2DM) that decreases the quality of life of T2DM patients. Very few studies have found an association between the development and progression of DPN in T2DM and angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms.
Using gene-specific primers in a polymerase chain reaction, the presence of ACE I/D polymorphisms was screened for in 276 T2DM patients with DPN, 496 T2DM patients without DPN, and 331 control (non-diabetic) subjects.
The distribution of the I/D genotypes was in Hardy-Weinberg equilibrium. The II genotype was significantly more prevalent in T2DM patients without DPN than the DD genotype (P < 0.05); however, there was no significant difference in the prevalence of the II and DD genotypes in T2DM patients with DPN (P = 0.78).
The II genotype of the ACE gene has a protective effect against the development of DPN in T2DM patients. This suggests a role for the renin-angiotensin system in modulating neuropathy in T2DM.
糖尿病周围神经病变（DPN）是 2 型糖尿病（T2DM）的并发症之一，降低了 T2DM 患者的生活质量。很少有研究发现 T2DM 患者 DPN 的发生和进展与血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性之间存在关联。
采用聚合酶链反应的基因特异性引物，对 276 例有 DPN 的 T2DM 患者、496 例无 DPN 的 T2DM 患者和 331 例对照（非糖尿病）受试者进行 ACE I/D 多态性筛查。
I/D 基因型的分布符合 Hardy-Weinberg 平衡。无 DPN 的 T2DM 患者中 II 基因型明显多于 DD 基因型（P<0.05）；但有 DPN 的 T2DM 患者中 II 和 DD 基因型的患病率无显著差异（P=0.78）。
ACE 基因的 II 基因型对 T2DM 患者 DPN 的发生具有保护作用。这表明肾素-血管紧张素系统在调节 T2DM 中的神经病变方面发挥作用。
