Eroglu Eray, Kocyigit Ismail, Unal Aydin, Sipahioglu Murat Hayri, Akgun Hulya, Kaynar Leylagul, Tokgoz Bulent, Oymak Oktay
Eray Eroglu, Ismail Kocyigit, Aydin Unal, Murat Hayri Sipahioglu, Bulent Tokgoz, Oktay Oymak, Division of Nephrology, Department of Internal Medicine, Erciyes University School of Medicine, 38039 Kayseri, Turkey.
World J Clin Cases. 2017 Mar 16;5(3):119-123. doi: 10.12998/wjcc.v5.i3.119.
Castleman's disease (CD), also known as angiofolicular lymph node hyperplasia, is a rare heterogenous group of lymphoproliferative disorders. Histologically, it can be classified as hyaline vascular type, plasma cell type, or mixed type. Clinically two different subtypes of the CD are present: Unicentric and multicentric. Unicentric CD is generally asymptomatic and associated with hyaline vascular type, and its diagnoses depend on the localized lymphadenopathy on examination or imaging studies. However, multicentric CD presents with generalized lymphadenopathy and systemic symptoms including malaise, fever, night sweats, weight loss, and it is associated with the plasma cell type and mix type. Herein, we report a patient with unicentric CD of the plasma cell type without systemic symptoms, who developed end stage renal failure caused by amyloidosis 6 years after onset of CD.
卡斯尔曼病（CD），也称为血管滤泡性淋巴结增生，是一组罕见的异质性淋巴增殖性疾病。在组织学上，它可分为透明血管型、浆细胞型或混合型。临床上存在两种不同亚型的CD：单中心型和多中心型。单中心型CD通常无症状，与透明血管型相关，其诊断依赖于检查或影像学研究发现的局限性淋巴结病。然而，多中心型CD表现为全身性淋巴结病和全身症状，包括不适、发热、盗汗、体重减轻，且与浆细胞型和混合型相关。在此，我们报告一例单中心浆细胞型CD患者，无全身症状，在CD发病6年后因淀粉样变性发展为终末期肾衰竭。
