Fengfeng Wu, Ruqing Ye, Juntao Xu
Department of Orthopedics, The Central Hospital of Huzhou City Zhejiang Province 313000 PR China.
Department of Orthopedics, The Affiliated Hospital of School of Medicine of Ningbo University 315020 PR China.
Open Med (Wars). 2016 Apr 18;11(1):101-105. doi: 10.1515/med-2016-0020. eCollection 2016.
The association between GSTP1 A>G polymorphism and chemosensitivity of osteosarcoma is controversial according to previously published studies. We conducted this meta-analysis to further investigate the role of GSTP1 A>G genetic variation in response to chemotherapy resistance in patients with osteosarcoma. Using the electronic databases of Pubmed, Wanfang and CNIK were searched to find the studies related to the GSTP1 A>G polymorphism and chemosensitivity of osteosarcoma. The genotype of AA, AG and GG were extracted from the chemotherapy sensitivity and chemotherapy resistance group. The association between GSTP1 A>G polymorphism and chemosensitivity was calculated by STATA11.0 software. The correlation between GSTP1 A>G polymorphism and chemotherapy response was assessed by odds ratio (OR) and its 95% confidence interval (95%CI). Four studies with 681 cases were finally included in this meta-analysis. The pooled data indicated that there was no significant association between GSTP1 A>G polymorphism and chemosensitivity in patients with osteosarcoma [Homozygous genetic model (GG vs AA): OR=0.53, 95%CI: 0.25-1.12, P=0.10; recessive genetic model (GG vs GA+AA): OR=0.61, 95%CI:0.34-1.11,P=0.11; and dominant genetic model (GG+AG vs AA): OR=0.67, 95%CI:0.42-1.07,P=0.10]. No correlation between GSTP1 A>G polymorphism and chemosensitivity was found according to this present meta-analysis. However, the small number of cases in each included study and significant statistical heterogeneity among the trials means the conclusion should be regarded as conservative.
根据先前发表的研究，GSTP1 A>G基因多态性与骨肉瘤化疗敏感性之间的关联存在争议。我们进行了这项荟萃分析，以进一步研究GSTP1 A>G基因变异在骨肉瘤患者化疗耐药反应中的作用。通过检索Pubmed、万方和中国知网的电子数据库，查找与GSTP1 A>G基因多态性和骨肉瘤化疗敏感性相关的研究。从化疗敏感组和化疗耐药组中提取AA、AG和GG基因型。使用STATA11.0软件计算GSTP1 A>G基因多态性与化疗敏感性之间的关联。通过比值比（OR）及其95%置信区间（95%CI）评估GSTP1 A>G基因多态性与化疗反应之间的相关性。最终，本荟萃分析纳入了4项研究，共681例病例。汇总数据表明，GSTP1 A>G基因多态性与骨肉瘤患者的化疗敏感性之间无显著关联[纯合子遗传模型（GG vs AA）：OR=0.53，95%CI：0.25-1.12，P=0.10；隐性遗传模型（GG vs GA+AA）：OR=0.61，95%CI：0.34-1.11，P=0.11；显性遗传模型（GG+AG vs AA）：OR=0.67，95%CI：0.42-1.07，P=0.10]。根据本荟萃分析，未发现GSTP1 A>G基因多态性与化疗敏感性之间存在相关性。然而，每项纳入研究中的病例数量较少，且各试验之间存在显著的统计学异质性，这意味着该结论应被视为保守的。
