谷胱甘肽 S-转移酶 P1(rs1695) 多态性与口腔癌风险的关联分析：文献综述、更新的荟萃分析和结构评估。
Association Analysis of GSTP1-rs1695 Polymorphism with the Risk of Oral Cancer: A Literature Review, an Updated Meta- Analysis, and a Structural Assessment.
机构信息
Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran.
Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Asian Pac J Cancer Prev. 2022 Nov 1;23(11):3859-3868. doi: 10.31557/APJCP.2022.23.11.3859.
BACKGROUND
This study aimed to investigate the association of rs1695 polymorphism in glutathione S-transferase P1 (GSTP1) with risk of oral cancer in a meta-analysis which was followed by a bioinformatics approach.
MATERIALS AND METHODS
Related articles were collected through a systematic search in PubMed, Google Scholar, and EMBASE databases up to June 2022 and then screened. Finally, seven studies, including 1249 cases of oral cancer and 1861 healthy individuals, were included in our meta-analysis. Seven different genetic models including G vs. A, GG+GA vs. AA, GG vs. GA+AA, GA vs. GG+AA, GG vs. GA, GG vs. AA, and GA vs. AA were used for the calculation of odds ratio and 95% confidence interval in order to assess the association between GSTP1-rs1695 polymorphism and oral cancer risk. Also, the ethnicity-based stratified analyses were performed using the seven mentioned models. Some bioinformatics software was used to investigate the effect of rs1695 polymorphism on the primary, secondary, and three-dimensional structure of GSTP1.
RESULTS
Our results showed that rs1695 polymorphism was not associated with the risk of oral cancer in any seven genetic models (G vs. A: OR= 0.9331, 95%CI= 0.6339-1.3737, P= 0.726; GG vs. GA+AA: OR= 0.9112 , 95%CI= 0.6865-1.2093, P= 0.520; GG+GA vs. AA: OR= 0.9006, 95%CI= 0.5522-1.4690, P= 0.675; GA vs. GG+AA: OR= 0.8732, 95%CI= 0.5763-1.3230, P= 0.522; GG vs. AA: OR= 0.9516, 95%CI= 0.5503-1.6456, P= 0.859; GG vs. GA: OR= 1.0645, 95%CI= 0.7891-1.4359, P= 0.683; GA vs. AA: OR= 0.8825, 95%CI= 0.5499-1.4162, P= 0.604). Also, we did not observe any significant associations in ethnicity-based stratified analyses. But bioinformatics studies have shown that this polymorphism can alter the physicochemical properties and secondary structure of the protein.
CONCLUSIONS
Based on results, the rs1695 polymorphism could not be considered a risk factor for oral cancer.
背景
本研究旨在通过系统检索 PubMed、Google Scholar 和 EMBASE 数据库，收集截至 2022 年 6 月的相关文献，并进行荟萃分析和生物信息学分析，以探讨谷胱甘肽 S-转移酶 P1（GSTP1）rs1695 多态性与口腔癌风险的关联。
材料与方法
采用系统检索 PubMed、Google Scholar 和 EMBASE 数据库，收集截至 2022 年 6 月的相关文献，并进行筛选。最终纳入 7 项研究，包括 1249 例口腔癌病例和 1861 例健康对照，采用 G vs. A、GG+GA vs. AA、GG vs. GA+AA、GA vs. GG+AA、GG vs. GA、GG vs. AA 和 GA vs. AA 7 种不同的遗传模型计算比值比（OR）和 95%置信区间（CI），以评估 GSTP1-rs1695 多态性与口腔癌风险的关联。此外，还采用上述 7 种模型进行基于种族的分层分析。使用一些生物信息学软件分析 rs1695 多态性对 GSTP1 一级、二级和三维结构的影响。
结果
我们的结果显示，rs1695 多态性与口腔癌风险在任何 7 种遗传模型中均无显著关联（G vs. A：OR=0.9331，95%CI=0.6339-1.3737，P=0.726；GG vs. GA+AA：OR=0.9112，95%CI=0.6865-1.2093，P=0.520；GG+GA vs. AA：OR=0.9006，95%CI=0.5522-1.4690，P=0.675；GA vs. GG+AA：OR=0.8732，95%CI=0.5763-1.3230，P=0.522；GG vs. AA：OR=0.9516，95%CI=0.5503-1.6456，P=0.859；GG vs. GA：OR=1.0645，95%CI=0.7891-1.4359，P=0.683；GA vs. AA：OR=0.8825，95%CI=0.5499-1.4162，P=0.604）。此外，基于种族的分层分析也未发现显著关联。但生物信息学研究表明，该多态性可能改变蛋白质的理化性质和二级结构。
结论
基于研究结果，rs1695 多态性不能被视为口腔癌的危险因素。
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