Dzamko Nicolas L
School of Medical Sciences, University of NSW, Kensington, NSW, 2052, Australia.
Neuroscience Research Australia, Randwick, NSW, 2031, Australia.
Adv Neurobiol. 2017;14:123-143. doi: 10.1007/978-3-319-49969-7_7.
Polymorphisms in leucine-rich repeat kinase 2 (LRRK2) have been linked to familial Parkinson's disease, increased risk of sporadic Parkinson's disease, increased risk of Crohn's inflammatory bowel disease, and increased susceptibility to leprosy. As well as LRRK2 mutations, these diseases share in common immune dysfunction and inflammation. LRRK2 is highly expressed in particular immune cells and has been biochemically linked to the intertwined pathways regulating inflammation, mitochondrial function, and autophagy/lysosomal function. This review outlines what is currently understood about LRRK2 function in the immune system and the potential implications of LRRK2 dysfunction for diseases genetically linked to this enigmatic enzyme.
富含亮氨酸重复激酶2（LRRK2）的多态性与家族性帕金森病、散发性帕金森病风险增加、克罗恩炎性肠病风险增加以及麻风易感性增加有关。除了LRRK2突变外，这些疾病还共同存在免疫功能障碍和炎症。LRRK2在特定免疫细胞中高度表达，并且在生物化学上与调节炎症、线粒体功能和自噬/溶酶体功能的相互交织的途径相关联。本综述概述了目前对LRRK2在免疫系统中的功能的理解，以及LRRK2功能障碍对与这种神秘酶存在遗传关联的疾病的潜在影响。
